肠道菌群在肝性脑病中的作用机制

Mechanism of action of intestinal flora in hepatic encephalopathy

肝性脑病临床症状多样,病因及发病机制目前尚未完全清楚,近年来研究发现肠道菌群组成与肝性脑病患者的中枢神经系统改变有关。在近年来国内外相关研究的基础上,从微生物学、神经系统及免疫学的角度分析并总结了肠道菌群通过肝-脑轴对肝性脑病的调控机制,认为深入研究肠道菌群的作用机制对肝性脑病的治疗很有必要,可为临床提供更明确的诊疗依据。

Hepatic encephalopathy(HE)has various clinical symptoms,and its etiology and pathogenesis have not been fully understood.Recent studies have shown that the composition of intestinal flora is associated with the changes in the central nervous system in patients with HE.With reference to recent studies in China and foreign countries,this article analyzes and summarizes the regulatory mechanism of intestinal flora on HE through the liver-brain axis from the perspectives of microbiology,nervous system,and immunology,and it is pointed out that in-depth studies on the mechanism of action of intestinal flora are needed for the treatment of HE and can provide a clear basis for clinical diagnosis and treatment.