摘要
当前我国大环内酯类抗菌药物耐药百日咳存在病例增多趋势,并可能持续数年。此文旨在对耐药百日咳的流行情况、临床特点及临床诊疗,耐药菌株的耐药相关分子机制,流行菌株抗原性的变异等方面进行简要陈述。
Currently,pertussis cases caused by macrolide-resistant Bordetella pertussis(B.pertussis)infection have already showed an increasing trend in China and can last for several years.This review aims to briefly describe the epidemic situation,clinical characteristics and clinical diagnosis and treatment of drug-resistant pertussis,the molecular characteristics of drug-resistance,and the antigenicity variation of pertussis strains.
作者
陈小春
刘琦
陈益平
Chen Xiaochun;Liu Qi;Chen Yiping(Department of Children's Infection,the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou 325027,Zhejiang,China)
出处
《国际流行病学传染病学杂志》
CAS
2020年第1期1-6,共6页
International Journal of Epidemiology and Infectious Disease
关键词
百日咳
大环内酯类
分子特征
抗原相关基因
Whooping cough
Macrolide antibiotics
Molecular characteristics
Antigenicity-associated genotype
