诱发矽肺动物模型方法及评价

Methods and Evaluation of Animal Models of Induced Silicosis

矽肺是在生产过程中长期吸入较高浓度的粉尘引起的以肺部纤维化为主的职业性疾病,是最为常见的职业病。矽肺的发病机制长期以来国内外都在研究,为探究矽肺的发病机制,研究治疗方法,建立动物模型至关重要。该文通过对矽肺动物模型的相对全面的介绍,为矽肺的临床研究应用提供更多的选择。

Silicosis is an occupational disease mainly caused by pulmonary fibrosis caused by long-term inhalation of high concentrations of dust during the production process. It is the most common occupational disease. The pathogenesis of silicosis has been studied at home and abroad for a long time. It is essential to explore the pathogenesis of silicosis,study treatment methods,and establish animal models. This article provides a more comprehensive selection of clinical research applications for silicosis through a relatively comprehensive introduction to silicosis animal models.