唑来膦酸联合射频手术治疗老年肺癌骨转移性癌痛

Clinical efficacy of zoledronic acid combined with radiofrequency surgery in treatment of bone metastatic cancer pain in elderly lung cancer patients

目的探究唑来膦酸联合射频手术治疗老年肺癌骨转移性癌痛的临床疗效。方法选择我院2017年1月~2018年1月收治的72例老年肺癌骨转移性癌痛患者,按照随机数字法分为观察组(36例)和对照组(36例)。对照组给予唑来膦酸治疗,观察组给予唑来膦酸联合射频手术治疗。比较两组患者治疗前后的疼痛数字评分(NRS)、一般状况评分(KPS)情况、骨质修复率;治疗后6个月对患者进行随访,比较两组患者疼痛缓解时间与活动状况。比较治疗结束时和结束6个月后的疗效。结果观察组患者的疼痛NRS评分低于对照组(P<0.05);观察组患者生活质量改善情况、骨质修复率、治疗结束时和治疗后6个月疗效明显高于对照组(P<0.05);观察组患者的疼痛缓解时间和活动能力明显优于对照组(P<0.05)。结论唑来膦酸联合射频手术治疗老年肺癌骨转移性疼痛,临床疗效及镇痛效果好,能有效缓解疼痛,提高患者的生活质量和骨质修复率,是治疗老年肺癌骨转移性癌痛的理想方案。

Objective To investigate the clinical efficacy of zoledronic acid combined with radiofrequency surgery in treatment of bone metastatic cancer pain in elderly lung cancer patients.Methods 72 elderly lung cancer patients with bone metastatic cancer pain treated in our hospital from Jan 2017 to Jan 2018 were selected and divided into control group and observation group,according to the random number method.The control group received the zoledronic acid.Based on zoledronic acid,the observation group received the radiofrequency surgery.The pain degree,Karnofsky performance score(KPS)and bone reparation rate of the two groups were compared and analyzed.The pain relief time,activity ability and clinical efficacy were recorded during the 6 mon-follow-up.Results The NRS score,quality of life,bone reparation rate and efficacy immediately after treatment and 6 mon after treatment in the observation group were better than those of the control group(P<0.05).The pain relief time and activity ability in the observation group were significantly better than those in the control group(P<0.05).Conclusion The zoledronic acid combined with radiofrequency surgerycan effectively relieve pain,improve the patient’s quality of life and bone reparation rate for elderly lung cancer patients with bone metastatic cancer pain.