大株红景天联合脑苷肌肽治疗糖尿病神经病变的疗效观察

Clinical observation on the effect of Rhodiola kirilowii regel combined with cattle encephalon glycoside and lgnotin on diabetic peripheral neuropathy

目的探讨大株红景天联合脑苷肌肽治疗糖尿病周围神经病变(DPN)的临床疗效。方法选取大同市第五人民医院2015年1月至2016年12月收治的90例糖尿病周围神经病变患者,随机分为大株红景天组、脑苷肌肽组、大株红景天与脑苷肌肽联合组,各30例。疗程结束后,评价3组治疗总有效率;观察治疗前后正中神经、腓总神经运动神经传导速度(MCV)、感觉神经传导速度(SCV)以及正中神经、腓总神经运动神经波幅(MAMP)、感觉神经波幅(SAMP)的变化;3组行视觉模拟评分(VAS)进行疼痛分析比较。结果治疗后,联合组总有效率明显高于其他两组(P<0.05);治疗后,3组正中神经SCV、MCV比较差异具有统计学意义(F=3.458、3.527,P=0.046、0.044);治疗后,3组腓总神经SCV比较差异具有统计学意义(F=3.757,P=0.036),3组腓总神经MCV比较差异无统计学意义(F=3.259,P=0.054);治疗后,3组正中神经SAMP比较差异无统计学意义(F=3.336,P=0.062),3组正中神经MAMP比较差异具有统计学意义(F=3.931,P=0.041);治疗后,3组腓总神经SAMP、MAMP比较差异具有统计学意义(F=3.811、4.685,P=0.044、0.025);治疗后,3组VAS评分均下降(F=3.607,P<0.05)。结论大株红景天联合脑苷肌肽治疗糖尿病周围神经病变效果,值得推广。

Objective To assess the clinical effect of the combined Rhodiola kirilowii regel with cattle encephalon glycoside and lgnotin on diabetic peripheral neuropathy(DPN).Methods 90 patients with diabetic peripheral neuropathy admitted to the fifth people's hospital of datong city from January 2015 to December 2016 were selected,were randomly divided into Rhodiola kirilowii regel group,cattle encephalon glycoside and lgnotin group and combined group,with 30 cases in each group.Median nerve,common peroneus nerve,motor nerve conduction velocity(MCV)and sensory nerves conduction velocity(SCV)were detected,and median nerve,common peroneus nerve,motor nerve amplitude(MAMP)and sensory nerves amplitude(SAMP)were recorded.Visual Analogue Score(VAS)was analyzed and compared in the three groups.Results The effective rate of the combination group was higher than the other two groups(P<0.05),MCV and SCV of the three groups were improved after treatment(P<0.05).After treatment,the SCV and MCV of median nerve in three groups were statistically significant(F=3.458,3.527,P=0.046,0.044).After treatment,the SCV of common peroneal nerve in three groups were statistically significant(F=3.757,P=0.036),and the MCV of common peroneal nerve in three groups were not statistically significant(F=3.259,P=0.054).After treatment,there was no significant difference in the comparison of the three groups of the median nerve(F=3.336,P=0.062),while there was significant difference in the comparison of the three groups of the median nerve(F=3.931,P=0.041).After treatment,there was significant difference in the comparison of the three groups of the common peroneal nerve(F=3.811,4.685,P=0.044,0.025).After treatment,the VAS scores of the three groups were decreased(F=3.607,P<0.05).Conclusion It was effective to use Chinese medicine Rhodiola kirilowii regel combined with cattle encephalon glycoside and lgnotin in treating DPN.