不同浓度氯化钠溶液与0.1%甲硝唑注射液联合坐浴治疗白血病病人肛周感染的临床效果

Clinical effects of sitting bath with different concentrations of sodium chloride solution combinedwith 0.1% metronidazole on perianal infection of leukemia patients

[目的]探讨不同浓度氯化钠溶液与0.1%甲硝唑注射液联合坐浴治疗白血病病人肛周感染的临床效果.[方法]将2010年6月—2018年5月在我院血液科住院的202例病人随机分为试验1组(41例)、试验2组(42例)、试验3组(40例)、对照1组(39例)、对照2组(40例),试验1组、试验2组、试验3组分别采用0.9%氯化钠溶液、1.6%氯化钠溶液、3.0%氯化钠溶液联合0.1%甲硝唑注射液坐浴,对照1组采用0.1%甲硝唑溶液坐浴,对照2组采用高锰酸钾溶液坐浴.比较5组病人肛周感染治疗效果.[结果]试验2组、试验3组治疗效果优于对照1组,试验2组、试验3组治疗效果优于对照2组,试验2组、试验3组治疗效果优于试验1组,试验2组治疗效果优于试验3组(均P<0.05).[结论]1.6%氯化钠溶液和3.0%氯化钠溶液与0.1%甲硝唑注射液联合使用,治疗效果均优于单独使用0.1%甲硝唑溶液和高锰酸钾溶液,且1.6%氯化钠溶液与0.1%甲硝唑注射液联合使用对肛周感染治疗效果最佳.

Objective:To explore the clinical effects of siting bath with different concentrations sodium chloride solution combined with 0.1% metronidazole on perianal infection in patients with leukemia.Methods:A total of 202 patients in Hematology department of our hospital from June 2010 to May 2018,were randomly divided into experiment 1 group(41 patients),experiment 2 group(42 cases), experiment 3 groups(40 cases),control 1 group(39 cases)and control 2 group(40 cases).Patients in experiment 1 group,experiment 2 group,experiment 3 group received siting bath with 0.9% sodium chloride solution,1.6% sodium chloride solution,and 3.0% sodium chloride solution respectively,combined with 0.1% metronidazole injection.Patients in control 1 group received siting bath with 0.1% metronidazole solution.Patients in control 2 group received siting bath with potassium permanganate solution.The therapeutic effects of perianal infection of 5 groups was compared.Results:The therapeutic effects of experiment 2 group and 3 group were better than that of control 1 group.The therapeutic effects of experiment 2 group and 3 group were better than that of control 2 group.The therapeutic effects of experiment 2 group and 3 group were better than that of experiment 1 group.The therapeutic effect of experiment 2 group was better than that of experiment 3 group(all P<0.05).Conclusion:The therapeutic effects of siting bath with 1.6% sodium chloride solution and 3.0% sodium chloride solution combined with 0.1% metronidazole injection were better than that sitz bath with 0.1% metronidazole solution or potassium permanganate solution alone. What's more,the effect of 1.6% sodium chloride solution combined with 0.1% metronidazole injection was the best for perianal infection.