肾上腺嗜铬细胞瘤的临床病理特征分析

Clinicopathological analysis of adrenal pheochromocytoma

目的探讨肾上腺嗜铬细胞瘤(PCC)的临床病理特征。方法收集22例PCC患者的临床病历资料,分析临床表现、病理特征、免疫组织化学特征、鉴别诊断、治疗和预后。结果患者中位年龄46岁(23~67岁);男性13例、女性9例;临床常见症状包括高血压、腹胀腹痛;Ⅰ期10例、Ⅱ期12例;中位随访时间为72.5个月(14.9~117.7个月),其中1例复发、1例转移,其余患者均未发生复发及转移;CgA、Syn和CD56阳性表达率分别为95.2%、95.2%、100.0%,CK、Melan-A阴性表达率分别为90.5%和100.0%,Ki-67增殖指数低于10%,S100阳性表达率为76.2%。结论肾上腺PCC发病率低,但有转移和复发的可能,需要定期随访。

Objective To investigate the clinicopathological features of adrenal pheochromocytoma(PCC).Methods The clinical and pathological data of 22 cases of PCC were collected.The clinical manifestations,pathological characteristics,immunohistochemical characteristics,differential diagnosis,treatment and prognosis were analyzed.Results The median age of the patients was 46 years old(23-67 years old).There were 13 males and 9 females.Common clinical symptoms include hypertension,abdominal distention and abdominal pain.There were 10 patients in stage I and 12 patients in stage II.The median follow-up time was 72.5 months(14.9-117.7 months),of which 1 case had recurrence and 1 case had metastasis,while the rest had no recurrence or metastasis.The positive expression rates of CgA,Syn and CD56 were 95.2%,95.2%and 100.0%,respectively;the negative expression rates of CK and Melan-A were 90.5%and 100.0%,respectively;the Ki-67 proliferation index was less than 10%;and the positive S100 rate was 76.2%.Conclusion The incidence of adrenal PCC is low,but metastasis and recurrence are possible,requiring regular follow-up.