糖化血红蛋白检测在糖尿病前期的应用价值

Application Value of Glycosylated Hemoglobin in Pre-diabetes

目的探讨糖化血红蛋白检测在糖尿病前期的应用价值。方法选取本院就医的中老年患者246例为研究对象,按照血糖水平分为4组IFG(空腹血糖受损)组44例,IGT(糖耐量受损)组76例,DM(糖尿病)组58例,NGT(正常糖代谢)组68例,4组患者均检测糖化血红蛋白(HbA1C)、空腹血糖(FPG)和餐后2小时血糖(2hPG)作统计分析。结果DM组FPG、2hPG、HbA1c相较于NGT,IGT,IFG组差异具有统计学意义(P<0.05),DM组HbA1c水平为(8.60%±1.11%),明显高于NGT组(5.11%±0.51%),IGT组(6.16%±1.05%)以及IFG组(5.89%±0.95%),对比差异具有统计学意义(P<0.05)。HbA1C≥6.5%作为诊断糖尿病的切点,敏感性为93.1%,特异性为95.2%,阳性似然比为19.3,阴性似然比为0.07。在非糖尿病组中,HbA1c水平在5.7%~6.4%之间分布,差异有统计学意义(χ2=29.7,P<0.05)。结论糖化血红蛋白检测在糖尿病前期有重要临床价值。

Objective To investigate the application value of glycosylated hemoglobin in pre-diabetes.Methods A total of 246 middle-agedand elderly patients hospitalized were selected as subjects,and 44 patients with impaired fasting glucose(IFG)were divided according to blood glucose,There were 76 patients in the impaired glucose tolerance(IGT)group,58 patients in the diabetes(DM)group,and 68 patients in the normal glucose metabolism(NGT)group.All patients were tested for glycosylated hemoglobin(HbA1c),fasting blood glucose(FPG),and 2-hour postprandial blood sugar(2hPG)was used for statistical analysis.Results The FPG,2hPG and HbA1c in the DM group were significantly different from those in the NGT,IGT,and IFG groups(P<0.05),and the HbA1c level in the DM group was(8.60%±1.11%),which was significantly higher than that in the NGT group(5.15%±0.51%),IGT group(6.16%±1.05%)and IFG group(5.89%±0.95%).The contrast difference was significant(P<0.05).HbA1c≥6.5%as a cut-off point for diagnosis of diabetes.,sensitivity was 93.1%,specificity was 95.2%,positive likelihood ratio was 19.3,and negative likelihood ratio was 0.07.In non-diabetic group,HbA1c level was 5.7%,6.4%,There was a significant difference between the distributions(χ2=29.7,P<0.05).Conclusion The detection of glycosylated hemoglobin has important value in pre-diabetes.