急性胰腺炎患者睡眠状态对免疫状态的影响研究

Study of the Influence of Sleep State for Immune Status of Patients with Acute Pancreatitis

目的:探讨急性胰腺炎患者睡眠状态对免疫状态的影响程度,以为急性胰腺炎患者的相关临床实践提供借鉴和参考依据.方法:选取2016年10月至2017年12月自贡市第三人民医院收治的急性胰腺炎患者124例作为研究对象,按照睡眠状态情况分成睡眠障碍组(n=64)和非睡眠障碍组(n=60).比较2组患者的抑郁状态、焦虑状态等心理应激状态和免疫功能指标.结果:睡眠障碍组的SAS评分和SDS评分显著高于非睡眠障碍组,IgG、IgM、CD3+、CD4+、CD8+、中性粒细胞、淋巴细胞和红细胞显著低于非睡眠障碍组,差异有统计学意义(P<0.05);2组患者的IgA、CD4+/CD8+、白细胞比较,差异无统计学意义(P>0.05).结论:急性胰腺炎患者的睡眠障碍发生情况较为严重,同时,随着患者睡眠状况的恶化,患者的抑郁状态和焦虑状态加剧,患者的免疫状态出现异常改变,临床上应根据急性胰腺炎患者的睡眠状态进行监控,并实施有针对性的早期干预.

Objective:To investigate the influence of sleep state for the immune status of patients with acute pancreatitis,so as to provide reference and reference for clinical practice of patients with acute pancreatitis.Methods:A Total of 124 patients with acute pancreatitis in Third People′s Hospital of Zigong City from October 2016 to December 2017 were divided into sleep disorder group 64 cases and t non-sleep disorder group 60 cases according to the patient′s sleep status.The psychological stress status included depressive state and anxiety state and immune function indicators of two groups were compared.Results:The SAS score and SDS score of sleep disorder group were significantly higher than those of non-sleep disorder group,and the differences were significant(P<0.05).The immune function indexes such as IgG,IgM,CD3+,CD4+,CD8+,neutrophils,lymphocytes and erythrocytes of sleep disorder group were significantly lower than those of non-sleep disorder group,there were statistically significant differences(P<0.05).The IgA,CD4+/CD8+and white blood cells of two groups were compared,there were no statistically significant differences(P>0.05).Conclusion:The occurrence of sleep disorders in patients with acute pancreatitis is more serious.At the same time,as the patient′s sleep condition deteriorates,the patient′s depression state and anxiety state are intensified,and the patient′s immune status changes abnormally.It is clinically necessary to monitor the sleep state of patients with acute pancreatitis and implement targeted early intervention.