健康新生儿粪钙卫蛋白水平及影响因素

The levels of fecal calprotectin in healthy neonates and its influence factors

目的 探讨不同因素对健康新生儿粪钙卫蛋白(fecal calprotectin,FC)的影响。方法 收集2017年12月-2018年12月在长治医学院附属和平医院产科出生的66例健康新生儿的第一次胎粪标本,并记录健康新生儿的一般资料。采用ELISA法检测FC水平。结果 对66例健康足月儿的粪便样本进行分析,其中男54例,女12例;顺产28例,剖腹产38例;母乳喂养28例,混合喂养38例,胎龄为39.3(38.3~40.3)周;出生体重为3575(2900~4250) g。男性和女性新生儿胎粪中FC水平中位数分别为712.99(363.24~1049.80)μg/g和666.04(538.12~1250.59)μg/g,FC水平差异无统计学意义(P=0.464);母乳喂养和混合喂养的新生儿胎粪中FC水平中位数为719.48(363.24~1250.59)μg/g和700.04(431.20~910.55)μg/g,FC水平差异无统计学意义(P=0.763);顺产和剖宫产新生儿胎粪FC水平中位数为716.24(363.24~1250.59)μg/g和810.15(431.20~1049.80)μg/g,差异有统计学意义(P<0.05)。结论 不同性别和喂养方式健康新生儿胎粪中FC水平无影响,不同的分娩方式胎粪中FC水平差异较大。

Objective To investigate the influence factors of fecal calprotectin(FC)in healthy neonates.Methods Sixty-six stool samples of healthy neonates were collected in the affiliated Heping hospital of Changzhi Medical College from December 2017 to December 2018,and the general data were recorded.The FC concentration was determined by the ELISA method.Results In this study,fecal samples were collected in a total of 66 cases,from whom were healthy and all full-term neonates,including 54 males and 12 females,28 cases were spontaneous labor and 38 cases were caesarean section,28 cases of breast feeding and 38 cases of mixed feeding,the mean gestational age was 39.3(38.3~40.3)weeks,and the averagebirth weight was 3575(2900~4250)g.The median calprotectin concentrations in males and females were 712.99(363.24~1049.80)μg/g and 666.04(538.12~1250.59)μg/g respectively.There was no significant difference in FC levels(P=0.464).The median calprotectin concentrations in breast feeding and mixed feeding neonates were 719.48(363.24~1250.59)μg/g and 700.04(431.20~910.55)μg/g respectively,there was no significant difference(P=0.763).The median calprotectin concentrations in spontaneous labor and caesarean section neonates were 716.24(363.24~1250.59)μg/g and 810.15(431.20-1049.80)μg/g respectively,the difference in FC levels is statistcally significant(P<0.05).Conclusions No influences were found in relation to gender and feeding ways.The delivery mode had large difference.