新诊断2型糖尿病患者血清CTRP12水平与相关因素分析

Analysis of serum CTRP12 levels and related factors in patients newly diagnosed type 2 diabetes

目的 探讨新诊断2型糖尿病(T2DM)患者血清CTRP12水平及其与糖脂代谢指标及胰岛素抵抗的相关性。方法 选择2018年11月-2019年5月本院初诊断的T2DM患者60例作为研究对象,按身体质量指数(BMI)分为两组,其中BMI≥25 kg/m2的30例为T2DM肥胖组,BMI <25 kg/m2的30例为T2DM非肥胖组,同时段健康体检者30例作为正常对照组。分别记录各组研究对象的一般资料及相关指标,如低密度脂蛋白(LDL-C)、甘油三酯(TG)、胆固醇(TC)、空腹血糖(FPG)、高密度脂蛋白(HDL-C)、糖化血红蛋白(Hb A1c)、空腹胰岛素(FIns),计算胰岛素抵抗指数及胰岛β细胞功能指数。采用ELisa法检测血清CTRP12水平。结果 (1)血清CTRP12水平在正常对照组、T2DM非肥胖组、T2DM肥胖组中依次降低。(2)血清CTRP12水平与LDL-C、TG、TC、FPG、Hb A1c、FIns等呈负相关,与胰岛β细胞功能指数呈正相关。结论 新诊断2型糖尿病患者与健康体检者相比血清CTRP12水平明显降低,血清CTRP12水平变化与糖脂代谢及胰岛素抵抗密切相关。

Objective To investigate the serum CTRP12 level of patients with newly diagnosed type 2 diabetes mellitus(T2DM),and its relationship with glucose and lipid metabolism index and insulin resistance.Methods Sixty newly diagnosed patients,with T2DM in the first affiliated hospital of Jiamusi University during November 2018 and May 2019,were selected and divided into two groups according to body mass index(BMI).Among them,30 patients with BMI(≥25 kg/m2)were in obese T2DM group,30 patients with BMI(<25 kg/m2)were in non-obese T2DM group,and 30 healthy people were taken as normal control group in the same period.The general data and related indicators such as low density lipoprotein(LDL-C),triglyceride(TG),cholesterol(TC),fasting blood glucose(FPG),high density lipoprotein(HDL-C),glycated hemoglobin(HbA1c),fasting insulin(FIns)of each group were recorded,insulin resistance index and islet beta cell function index were calculated.Serum CTRP12 levels were measured by the ELISA method.Results The level of serum CTRP12 decreased successively in the normal control group,the non-obese T2DM group and the obese T2DM group.Serum CTRP12 level was negatively correlated with LDL-C,TG,TC,FPG,HbA1c,FIns and positively correlated with islet beta cell function index.Conclusions The level of serum CTRP12 in newly diagnosed type 2 diabetes mellitus is significantly lower than that in healthy subjects.The change of serum CTRP12 level is closely related to glycolipid metabolism and insulin resistance.