糖调节受损患者静态平衡功能减退的临床观察

Static balance dysfunction in patients with impaired glucose regulation

目的评估糖调节受损(IGR)人群的静态平衡功能。方法选取2016年7月至2017年8月就诊于首都医科大学附属复兴医院内分泌科的IGR患者(IGR组)29例,其中男13例,女16例,年龄(49.69±6.13)岁。选取同期健康体检人群24名为对照组(Con组),其中男5名,女19名,年龄(46.37±7.19)岁。收集两组受试者一般资料及内分泌相关化验结果,应用静态平衡仪评估静态平衡功能,评估指标包括单位面积轨迹长(UAL)、轨迹总长度、最远距离、轨迹图面积、Romberg率。两组间均数比较符合正态分布的采用两独立样本t检验,不符合正态分布的采用Mann-Whitney U检验,率的比较采用χ2检验。结果(1)睁眼站立于硬平台时,IGR组轨迹图面积、轨迹总长度、最远距离、UAL与Con组比较,差异均无统计学意义(t=1.302~1.583,P>0.05);(2)闭眼站立于硬平台时,IGR组轨迹图面积[(829.22±299.48)比(337.23±161.69)mm]、轨迹总长度[(1035.17±354.77)比(835.75±299.48)mm]及最远距离[(55.38±21.89)比(39.71±9.22)mm]、Romberg率[(1.83±0.98)比(1.25±0.58)%]均大于Con组(t=3.633、2.019、3.499、2.666,P<0.05),UAL小于Con组[(1.79±0.87)比(2.76±1.22)mm,t=-3.332,P=0.002]。结论睁眼情况下IGR患者站立位静态平衡功能较正常人群无差异,而在剥夺视觉情况下IGR患者站立位静态平衡功能较正常人群下降;Romberg率增大提示IGR患者维持站立位静态平衡功能更多依赖视觉代偿。

Objective To evaluate the static balance function in patients with impaired glucose regulation.Methods Twenty-nine patients[13 males and 16 females,mean age(49.69±6.13)years]with impaired glucose regulation(IGR group)were recruited from Fuxing Hospital of Capital Medical University between July 2016 and August 2017,and 24 healthy controls[5 males and 19 females,(46.37±7.19)years,Con group]were recruited in the same period.General baseline data and endocrine-related test results were collected.Static balancing apparatus was used to evaluate the balance function of the subjects.The evaluation indexes include the unit area statokinesigram length(UAL),total length of the track,maximum amplitudes,the surface of statokinesigram area(SSKG)and Romberg quotient.Two independent samples t test was used to compare the mean of the two groups with normal distribution,Mann-Whitney U test was used to compare the data with non-normal distribution,andχ2 test was used to compare the rates.Results (1)When standing on the hard platform with eyes opened,there was no statistically significant differences in SSKG,total length of the track,maximum amplitudes and UAL between IGR group and Con group(t=1.302-1.583,P>0.05);(2)When standing on the hard platform with eyes closed,SSKG,total length of the track,maximum amplitudes and Romberg quotient were all higher in IGR group than those in Con group[(829.22±299.48)vs(337.23±161.69)mm;(1035.17±354.77)vs(835.75±299.48)mm;(55.38±21.89)vs(39.71±9.22)mm;(1.83±0.98)vs(1.25±0.58)%,respectively],and the UAL in IGR group was lower than that in Con group[(1.79±0.87)vs(2.76±1.22)mm,t=-3.332,P=0.002].Conclusion When eyes open,there is no difference in the static balance function between IGR group and control group.under the condition of visual deprivation,the static balance function in IGR group is lower than that in con group;the increase of Romberg quotient indicates that the maintenance of standing static balance function in IGR patients depends more on visual compensation.