玻璃酸钠滴眼液点眼对中重度干眼及无干眼IOL-Master 700生物测量参数的影响

Effect of sodium hyaluronate eye drops on IOL-Master 700 measurement parameters in moderate and severe dry eye and non dry eye patients

目的研究玻璃酸钠滴眼液点眼对中重度干眼及无干眼者IOL-Master 700生物测量参数的影响。方法采用非随机对照临床研究方法。招募2018年8月1日至2019年1月1日于解放军总医院第一医学中心眼科门诊就诊的中重度干眼患者作为中重度干眼组,同期选取无干眼者作为无干眼组,每组各40例,均以右眼为试验眼。所有受试者分别于质量分数0.1%玻璃酸钠滴眼液点眼前、点眼后5、10及15 min行IOL-Master 700生物测量,分析2个组玻璃酸钠点眼前后不同时间眼轴长度(AL)、中央角膜厚度(CCT)、角膜曲率、人工晶状体(IOL)度数的变化。结果中重度干眼组CCT、K1和K2均大于无干眼组,差异均有统计学意义(均P<0.05)。中重度干眼组玻璃酸钠滴眼液点眼后5 min和10 min,AL、CCT及IOL度数较点眼前增大,K1较点眼前减小,差异均有统计学意义(均P<0.05/3);点眼后5 min,17.5%(7/40)中重度干眼患者的IOL度数增大0.5 D。点眼后10 min,22.5%(9/40)的中重度患者IOL度数增大0.5 D或1.0 D。点眼后15 min,各IOL-Master测量参数与点眼前比较,差异均无统计学意义(均P>0.05)。无干眼组点眼后5 min AL和CCT较点眼前增大,IOL度数较点眼前减小,差异均有统计学意义(均P<0.01)。点眼后10 min及15 min,AL和CCT较点眼前增大,差异均有统计学意义(均P<0.05/3),但IOL度数比较差异无统计学意义(均P>0.05)。结论玻璃酸钠滴眼液点眼后5~10 min IOL-Master生物测量中重度干眼患者IOL度数增大,点眼后5 min内无干眼者IOL度数减小,该结果对临床上IOL-Master的正确使用有指导意义。

Objective To assess the changes in IOL-Master 700 parameters after administering sodium hyaluronate eye drops to moderate and severe dry eye and non-dry eye patients.Methods Non-randomized controlled clinical research was performed.Patients with moderate and severe dry eye and non dry eye were enrolled in this study,with 40 patients in each group.All patients underwent IOL-Master 700 bioassay before and 5,10 and 15 minutes after the administration of 0.1%sodium hyaluronate eye drops.The differences in axial length(AL),central corneal thickness(CCT),corneal curvature,and intraocular lens(IOL)were compared before and after the administration.All subjects signed informed consent.Results In the dry eye group,the AL,CCT and IOL power were increased and the K1 were decreased at 5 and 10 minutes after administering sodium hyaluronate eye drops(P<0.05/3).IOL power of 17.5%increased by 0.5 D at 5 minutes after administering sodium hyaluronate eye drops.Further,22.5%IOL power increased by 0.5 D or 1.0 D at 10 minutes after administering sodium hyalruonate eye drops.At 15 minutes after the administration,the IOL-Master parameters returned to the pre-intervention level.For the non-dry eye group,the AL and CCT were increased at 5 minutes after administering sodium hyalruonate eye drops,and the IOL power was decreased(P<0.01).The IOL power was decreased by a maximum of 0.5 D.At 10 and 15 minutes after administering sodium hyalruonate eye drops,the AL and CCT were significantly higher than those before the administration(all at P<0.05/3),but there was no significant change in IOL power(P>0.05).Conclusions The IOL power of moderate and severe dry eye patients is increased at 5-10 minutes after administering sodium hyaluronate eye drops,and the IOL power of non-dry eye patients is decreased within 5 minutes after the administration.