角膜胶原交联术治疗角膜病的新进展

Research advances of corneal collagen cross-linking in the treatment of corneal diseases

角膜胶原交联术(CXL)对阻止扩张性角膜病、感染性角膜病、屈光不正的发展具有较好的安全性和有效性。常见CXL有常规胶原交联术、加速胶原交联术、跨上皮胶原交联术、激光化学反应胶原交联术以及联合手术。CXL可有效阻止扩张性角膜病进展,可延迟或避免角膜移植手术的治疗,并在大泡性角膜病、除疱疹病毒性感染外的感染性角膜炎、屈光不正等其他角膜病的治疗中均有较好的辅助作用,但对于眼部疱疹病毒性感染的患者及薄角膜的患者效果不佳,甚至会加重病情发展。本文就常见CXL手术方式的优缺点、适应症、禁忌症以及并发症进行综述,以期增强CXL的临床应用,减少其并发症。

Corneal collagen cross-linking(CXL)has been proved to be a very safe and effective technique to halt the progression of many cornea diseases,such as ectasia disease,infectious keratitis and ametropia.CXL techniques include conventional CXL,accelerated CXL,transepithelial CXL and photochemical CXL.CXL can prevent the progression of dilated keratopathy,postpone or avoid corneal transplant surgery,and has an auxiliary function in the treatment of bullous keratopathy,infectious keratitis except herpes virus infection,and ametropia.CXL is not effective for patients with ocular herpes virus infection and patients with thin cornea and may even worsen the development of the disease.This review summarized the advantages and disadvantages of common CXL techniques,indications,contraindications,and complications,which may help enhancing the clinical application of CXL and reducing its complications.