普萘洛尔联合595 nm脉冲染料激光治疗婴幼儿血管瘤疗效观察

Therapeutic Effect of Propranolol Combined with 595 nm Pulsed Dye Laser in the Treatment of Infantile Hemangiomas

目的研究口服普萘洛尔联合595 nm脉冲染料激光治疗婴幼儿血管瘤疗效。方法选取2016年1月-2017年10月就诊于新疆维吾尔自治区人民医院皮肤性病科的婴幼儿血管瘤患儿60例,所有患儿被分为实验组及对照组,每组各30例患者。实验组患儿接受595 nm脉冲染料激光照射联合口服普萘洛尔治疗,对照组患儿仅接受595 nm脉冲染料激光治疗。结果实验组[96.67%(29/30)]疗效高于对照组[86.67%(26/30)],实验组患儿的愈合时间及激光治疗次数均少于对照组,差异有统计学意义(P<0.05)。两组患儿不良反应发生率差异无统计学意义。结论口服普萘洛尔联合595 nm脉冲染料激光治疗对于婴幼儿血管瘤患儿有显著疗效,相对于单纯激光治疗,联合治疗可以有效缩短治疗时间、提高治疗效果,未增加不良反应。

Objective To investigate the efficacy of propranolol combined with 595 nm pulsed dye laser in the treatment of infantile hemangiomas(IH).Methods A total of 60 cases of IH admitted to the People’s Hospital of Xinjiang Uygur Autonomous Region from January 2016 to October 2017 were enrolled in this study.They were divided into the control group and the experimental group,with 30 cases in each group.The infant patients in the control group were treated with 595 nm pulsed dye laser alone,and those in the experimental group were treated with oral propranolol combined with595 nm pulsed dye laser.Results The therapeutic effect was higher in experimental group[96.67%(29/30)]than in control group[86.67%(26/30)].The healing time and the times of laser therapy of the infant patients in the observation group were significantly less than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Oral propranolol combined with 595 nm pulsed dye laser has significant effects on children with IH.Compared with laser therapy alone,combination therapy can effectively shorten treatment time and improve therapeutic effect without increasing adverse reactions.Therefore,it is effective,safe,and worthy of popularization.