帕金森病视幻觉的结构及功能影像学研究现状

The research status of structural and functional imaging in Parkinson's disease with visual hallucinations

帕金森病(Parkinson's disease,PD)是一种常见的神经系统退行性疾病,主要以静止性震颤、远动迟缓及肌强直等运动症状为主要表现,但同时也可以合并各种非运动症状,如自主神经症状、认知障碍及精神症状等。视幻觉是PD患者最常见的精神症状,不仅严重影响PD患者的生活质量,还增加其住院率、病死率及照料者负担。但目前PD视幻觉的发生机制尚不明确。随着技术的发展,越来越多的结构及功能影像学检查被应用于PD视幻觉的研究,这些研究主要反映了PD伴视幻觉患者大脑的结构及功能改变,从而为进一步明确PD视幻觉的发生机制提供线索。

Parkinson's disease(PD)is a common neurodegenerative disease characterized by various motor and non-motor symptoms.Visual hallucinations are most common non-motor symptoms,which seriously affect the quality of life of PD patients,increase the hospitalization and mortality rate,and the burden of care,available data indicates that PD patients with visual hallucinations are more likely to develop cognitive impairment.However,the mechanism of PD with visual hallucinations are remain unclear.With the development of technologies,more and more structural and functional imaging research being conducted to detect the structural and functional changes in PD with visual hallucinations patients.