黄芪甲苷对心肌细胞保护作用机制的研究进展

The research on mechanism of the protective effect of astragaloside Ⅳ on cardiomyocytes

黄芪是一种传统中药材,具有补气升阳、固表止汗、利水消肿、托毒生肌等功效,在中国已经被广泛用于治疗心血管疾病,其中黄芪甲苷(AS-Ⅳ)是其重要的有效成分之一。黄芪甲苷的主要药理作用包括增强免疫力、抗炎、抗氧化、抗病毒等。近年开展的AS-Ⅳ相关研究表明,黄芪甲苷通过调节细胞内钙稳态、抗氧化反应、改善心肌能量代谢、抑制细胞凋亡、抗细胞毒性作用等多种机制参与心脏保护作用。本文就相关研究内容进行综述,以期对临床研究提供参考。

Astragaloside Ⅳ(AS-Ⅳ)is an active ingredient from a kind of traditional Chinese herbal medicine astragalus membranaceus,which has the functions of invigorating and promoting yang,fixing surface and relieving sweat,diffusing edema and detoxifying muscles.Chinese herbal medicine astragalus membranaceus has been widely used in the treatment of cardiovascular diseases in China,and AS-Ⅳ is one of its important active ingredients.The main pharmacological effects of AS-Ⅳ include the enhancement of immunity,anti-inflammatory,anti-oxidation and anti-virus.Recent studies on AS-Ⅳ demonstrated that AS-Ⅳ can participate in cardioprotection by regulating intracellular calcium homeostasis,anti-oxidation interaction,improving myocardial energy metabolism,inhibiting apoptosis and anti-cytotoxicity.This article concludes the relevant researches in order to provide reference for clinical study.