注射用化疗药物用药调查分析

Drug investigation analysis of chemotherapeutic drugs for injection

目的:对首都医科大学附属北京天坛医院(以下简称我院)注射用化疗药物使用情况进行点评,以提高化疗药物临床应用的合理性及安全性。方法:由我院信息中心导出2016年1月至2017年11月使用注射用化疗药物的患者用药医嘱,通过我院HIS系统,统计化疗患者的一般资料、诊断、使用的化疗方案及其剂量、溶媒、药物浓度、给药次序、给药速度及辅助化疗药物的使用情况等。结果:我院2016年1月至2017年11月间使用注射用化疗药物的患者共992例,共计9744条医嘱。不合理医嘱533条(5.5%),涉及患者121例(12.2%)。涉及不合理医嘱最多的前3位药物分别为依托泊苷注射液(459条,86.1%)、注射用奈达铂(28条,5.3%)、注射用培美曲塞二钠(25条,4.7%)。不合理医嘱中出现的用药差错主要为溶媒选用不当(481条,90.2%)以及诊断与用药不符(25条,4.7%)。结论:我院注射用化疗药物使用情况基本合理,但有些方面仍需进一步改进以保证患者的用药安全。

Objective:This study was designed to evaluate the use of chemotherapeutic drugs for injection in Beijing Tiantan Hospital(hereinafter referred to as our hospital) and improve the rationality and safety of chemotherapeutic drugs.Methods:The information of chemotherapeutic drugs from January 2016 to November 2017 was imported from our information center.Our HIS system was used to calculated the general information,diagnosis,chemotherapy used,dosage,vehicle,drug concentration,drug sequence,administration speed,and use of adjuvant chemotherapeutic drugs of chemotherapy patients.Results:From January 2016 to November 2017,there were 992 patients receiving chemotherapeutic drugs for injection in our hospital with totaled 9744 medical orders.Top three drugs involved in the problems were etoposide(459 pieces,86.1 %),nedaplatin(28 pieces,5.3%),and pemetrexed disodium(25 pieces,4.7%).The medication errors were mainly due to the wrong choice of solvents(481 pieces,90.2%) and discrepancies between diagnosis and medication(25 pieces,4.7%).Conclusion:The use of chemotherapeutic drugs for injection in our hospital is basically reasonable,but some aspects still need further improvement to ensure the safety of patients’ medication.