焦亡在常见消化道疾病中的机制研究

Mechanism of Pyroptosis in Common Digestive Tract Diseases

焦亡是一种促炎性程序性死亡,不同于凋亡或坏死,是细胞死亡的另一种形式,以胱天蛋白酶切割Gasdermin D介导膜孔形成为特征,最终膜破裂和细胞内容物泄漏,大量炎症介质释放。随着对细胞焦亡调节机制的深入研究和探讨,细胞焦亡在炎症、感染、免疫、肿瘤等疾病发生、发展中的作用越来越受到关注。细胞焦亡广泛参与消化系统各个脏器疾病的发生、发展及预后,如肝炎肝硬化、炎症性肠病、消化道肿瘤等,进一步阐述细胞焦亡各环节关键物质在胃肠道常见疾病中的发生机制具有重要意义。

Pyroptosis is a proinflammatory programmed death,which is different from apoptosis or necrosis,and is another form of cell death.It is characterized by caspase cleaved Gasdermin D mediated membrane pore formation,and finally membrane rupture,cell contents leakage and a large number of inflammatory mediators release.In the past decades,scholars have conducted in-depth research and discussion on the regulatory mechanism of pyroptosis,and now more and more attention has been paid to the role of pyroptosis in the occurrence and development of inflammation,infection,immunity,tumor and other diseases.Pyroptosis of cells is widely involved in the occurrence,development and prognosis of various viscera diseases of the digestive system,including hepatitis cirrhosis,inflammatory bowel disease,gastrointestinal tumor,etc.It is of great significance to further elucidate the mechanism of common diseases of gastrointestinal tract caused by the key substances in each link of pyroptosis.