52例原发性皮肤淀粉样变病因分析

Analysis of risk factors of the 52 patients with primary cutaneous amyloidosis

目的:明确原发性皮肤淀粉样变患者发病相关因素。方法:对2018年3月至2019年1月我院52例原发性皮肤淀粉样(PCA)变患者及104名正常对照的资料进行分析。结果:多因素Logistic回归分析显示原发性皮肤淀粉样变的发病因素中日光暴晒、搔抓、过敏为危险因素,OR值分别为3.044,9.254,4.653,P均<0.05。合并疾病中,湿疹、荨麻疹、过敏性鼻炎发病率在PCA患者与104名健康正常对照间比较,差异有统计学意义(P<0.05)。结论:日光暴晒、搔抓、过敏与原发性皮肤淀粉样变的发病有关,患者易合并湿疹、荨麻疹、过敏性鼻炎。

Objective:To determine the influence factors of primary cutaneous amyloidosis(PCA).Methods:The data of 52 patients with primary cutaneous amyloidosis(PCA)in our hospital from May 2018 to January 2019 was analyzed.Results:A multivariable unconditional logistic regression showed that the excess sunlight,scratching and allergy were associated risk factors(OR=3.04,9.25 and 4.65,respectively(Ps<0.05).There were significant differences in morbidity of eczema,urticaria and allergic rhinitis between 52 PCA patients and 104 healthy controls(P<0.05).Conclusion:The sunlight,scratching and allergy are associated with PCA and the complicating diseases include eczema,urticaria and allergic rhinitis.