东莞市儿童维生素D缺乏现状及与血小板参数的相关性研究

Correlation between vitamin D deficiency and platelet parameters of children in Dongguan

目的了解东莞市儿童维生素D(VD)缺乏的现状及其与血小板参数的相关性。方法采用回顾性调查的方法,选取自2017年1月-2018年3月期间在东莞市儿童医院健康体检并进行血常规和血清25-(OH)D检测的6个月~14岁儿童2337例,分析VD缺乏、VD不足的发生率及其与血小板参数的相关性。结果入组儿童VD缺乏和不足检出率分别为14.46%和25.03%,VD缺乏和不足检出率均为婴幼儿组<学龄前组<学龄组,VD缺乏检出率男女童差异无统计学意义(P>0.05),而VD不足检出率男童低于女童。随着年龄增长,25-(OH)D水平及血小板(PLT)计数降低,平均血小板体积(MPV)以及血小板分布宽度(PDW)则升高,差异具有统计学意义(P<0.05);不同性别之间25-(OH)D水平及血小板参数差异无统计学意义(P>0.05);VD不足和缺乏组与正常组之间的PLT计数、MPV、PDW差异具有统计学意义(P<0.05);而VD不足组和缺乏组之间差异无统计学意义(P>0.05)。进一步以VD分组为因变量,进行多因素Logistic回归分析,结果显示,VD缺乏和VD不足与年龄增加、MPV增高、PDW降低呈显著相关(P<0.05)。结论东莞市6个月~14岁儿童中VD缺乏和不足检出率均较高,随年龄增大,VD缺乏逐渐增加,需加强干预。此外,VD缺乏和不足可能与MPV增高及PDW降低具有一定的相关性。

Objective To understand the status of vitamin D(VD)deficiency of children in Dongguan and the relationship between vitamin D deficiency and platelet parameters.Methods A retrospective survey was used,and 2337 children aged 6 months-14 years were selected from the Department of Child Health Care.Blood routine and serum 25-hydroxyvitamin D[25-(OH)D]test have been done to analysis the incidence of vitamin D deficiency and its correlation with platelet parameters.Results The deficiency rate and insufficient rate of VD in children was 14.46%and 25.03%,respeltirely.VD deficiency rate and insufficient rate were highest in school-age group,followed by preschool group and infant group,The insufficient rate of VD in boys was lower than that in girls(P<0.05),but there was no significant difference on VD deficiency rate between different genders.With the increasing of age,25-(OH)D level and platelet(PLT)count decreased,mean platelet volume(MPV)and platelet distribution width(PDW)increased,and the difference was statistically significant(P<0.05).There were no statistically significant differences on 25-(OH)D level and platelet parameters between different genders(P>0.05);There were statistically differences on PLT count,MPV and PDW among VD deficiency group,VD insufficient were and normal group,while the difference between VD deficiency group and VD insufficient group was not statistically significant(P>0.05)The results of multi-classification Logistic regression analysis showed that VD deficiency and insufficient were correlated with age increasing,MPV increasing and PDW decreasing.Conclusions The deficiency rate and insufficient rate of VD in children are high.With the increasing of age,the rate of VD deficiency increases gradually,so the intervention needs to be strengthened.In addition,the deficiency of VD may be correlated with the increase of MPV and the decrease of PDW.