程序性坏死的信号转导机制及其在创伤性颅脑损伤中的研究进展

Signal Transduction Mechanisms of Programmed Necrosis and Its Research Progress in Traumatic Brain Injury

程序性坏死是近年发现的一种新型程序性死亡方式,其具有规律的基因调控机制及典型的坏死形态学特征,打破了传统意义上坏死的不可调控性。程序性坏死在创伤性颅脑损伤的发展及预后中扮演重要角色,其特异性抑制剂Nec-1(Necrostatin-1)可有效抑制程序性坏死的信号通路,明显减少颅脑创伤后神经细胞程序性坏死的发生,为创伤性脑损伤后的神经细胞修复提供新思路。但程序性坏死与其他细胞死亡方式间的联系及其有效抑制在人体创伤性颅脑损伤中的治疗效果仍需不断探索。

Programmed necrosis is a way of programmed death newly discovered in recent years,which has regular gene regulation mechanism and typical morphological characteristics of necrosis,breaking the uncontrollable nature of necrosis in the traditional sense. Programmed necrosis plays an important role in the development and prognosis of traumatic brain injury.Its specific inhibitor Necrostatin-1( Nec-1) can effectively inhibit the signal pathway of programmed necrosis and significantly reduce the occurrence of programmed necrosis of nerve cells after brain injury,providing a new idea for nerve cell repair after traumatic brain injury. However,the relationship between programmed necrosis and other modes of cell death and its effective inhibition in the treatment of traumatic brain injury still need to be continuously explored.