血清炎性因子水平对高血压合并糖耐量减低的临床影响

Clinical Effect of Serum Inflammatory Factors on Hypertension Complicated with Impaired Glucose Tolerance

目的探讨血清白介素-6(IL-6)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)对高血压合并糖耐量减低患者的临床影响。方法选取2018年5月—2019年6月就诊的高血压合并糖耐量减低患者100例作为研究组,随机抽取健康体检人群50例作为对照组。2组均动态监测血压,检测空腹血糖、餐后2 h血糖、空腹胰岛素水平,并计算胰岛素抵抗指数。比较2组以及不同级别高血压合并糖耐量减低患者的血清IL-6、TNF-α、CRP水平。结果与对照组比较,研究组的空腹血糖、餐后2 h血糖、收缩压、舒张压、胰岛素抵抗指数以及血清IL-6、CRP、TNF-α水平明显高于对照组(P<0.05)。在研究组中,3级高血压合并糖耐量减低患者的血清IL-6、CRP、TNF-α水平明显高于2级患者,2级患者的血清IL-6、TNF-α、CRP因子明显高于1级患者(P<0.05)。结论高血压合并糖耐量减低患者的血清IL-6、CRP、TNF-α水平较正常人群显著升高。在临床上,可以应用血清IL-6、TNF-α、CRP水平作为高血压合并糖耐量减低患者诊断的检测指标。

Objective To investigate the clinical effects of serum interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)on patients with hypertension complicated with impaired glucose tolerance.Methods A total of 100 patients with hypertension and impaired glucose tolerance who visited the hospital from May 2018 to June 2019 were selected as the research group,and 50 healthy people who underwent physical examination were randomly selected as the control group.Blood pressure was monitored dynamically in both groups,fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG),and fasting insulin levels were measured,and the insulin resistance index was calculated.The serum IL-6,TNF-α,and CRP levels of the two groups and patients with different levels of hypertension combined with impaired glucose tolerance were compared.Results Compared with the control group,FPG,2 hPG,systolic blood pressure,diastolic blood pressure,insulin resistance index,and serum IL-6,CRP,TNF-αlevels in the research group were significantly higher than those in the control group(P<0.05).In the research group,the serum levels of IL-6,CRP and TNF-αin patients with grade 3 hypertension and impaired glucose tolerance were significantly higher than those in patients with grade 2,and the serum levels of IL-6,TNF-αand CRP in patients with grade 2 were significantly higher than those in patients with grade 1(P<0.05).Conclusion The serum levels of IL-6,TNF-αand CRP in patients with hypertension and impaired glucose tolerance were significantly higher than those in healthy people.In clinical practice,serum levels of IL-6,TNF-αand CRP can be used as diagnostic indicators in patients with hypertension complicated with impaired glucose tolerance.