HECT型E3泛素连接酶在肿瘤中作用的研究现状和进展

Advances in the role of HECT-type E3 ubiquitin ligases in tumors

肿瘤的发生和发展是多因素、多步骤的复杂过程。而泛素化是多步级联的蛋白质修饰过程,是维持真核细胞内稳态的重要机制。其中E3泛素连接酶家族是泛素-蛋白酶体系统的重要成分,可催化多种蛋白底物的泛素化,促进其被蛋白酶体系统降解。迄今为止,E3泛素连接酶在多种肿瘤细胞生物学过程中发挥着重要作用,包括细胞增殖、凋亡及周期调控。而HECT型E3泛素连接酶作为E3泛素连接酶最早被研究的一种,其主要参与蛋白质翻译后转录调控的泛素化修饰过程。本文就HECT型E3泛素连接酶及其在肿瘤中作用的现状和最新研究进展进行综述。

The occurrence and development of tumors is a complex process with multiple factors and multiple steps.Ubiquitination refers to a multi-step cascade of protein modification processes including ubiquitin,ubiquitin-activating enzyme,ubiquitin-binding enzyme,ubiquitin ligase and proteasome,which is important for maintaining eukaryotic homeostasis.mechanism.The E3 ubiquitin ligases family is an important component of the ubiquitin-proteasome system.This family includes many proteins that catalyze the ubiquitination of various protein substrates and promote their degradation by the proteasome system.Up to date,E3 ubiquitin ligases has played an important role in a variety of tumor cell biology processes,including cell proliferation,apoptosis and cycle regulation.HECT-type E3 ubiquitin ligases,one of the earliest studies of E3 ubiquitin ligases,is involved in the ubiquitination of transcriptional regulation of protein translation.This article reviews the recent research progress of HECT-type E3 ubiquitin ligases and its role in tumors.