清热祛浊胶囊对痰湿郁热型2型糖尿病患者血管内皮功能的影响

Efficacy of the Qingre Quzhuo capsules on endothelial function in patients with T2DN of the Tanshi Yure type

目的:探究清热祛浊胶囊对痰湿郁热型2型糖尿病(Type 2 Diabetic Nephropathy,T2DN)患者血管内皮功能的保护作用。方法:将初诊的痰湿郁热型2型糖尿病患者60例随机分为对照组和清热祛浊胶囊组,每组各30例。两组患者均根据个体情况给予糖尿病饮食处方控制、健康教育及个体化运动指导等基础治疗,在此基础上,对照组给予二甲双胍肠溶片治疗,清热祛浊胶囊组在对照组治疗基础上联合清热祛浊胶囊治疗,两组均连续治疗12周。观察两组患者治疗12周后体质量指数(Body Mass Index,BMI)、血糖、糖化血红蛋白(Hemoglobin,HbA1c)、胰岛素抵抗指数(HOMA-IR)、血脂、内皮素-1(Endothelin-1,ET-1)、一氧化氮(Nitric Oxide,NO)水平变化情况,超声测定内皮依赖性血管舒张功能(FMD),评价两组患者中医证候积分。结果:治疗12周后,两组患者治疗后的中医证候积分有下降趋势,糖脂代谢、体质量指数、胰岛素抵抗均有所改善,血管内皮功能ET-1水平均有下降趋势,而NO、FMD则有所上升,以清热祛浊胶囊组的变化程度更为明显。结论:清热祛浊胶囊利于减轻痰湿郁热型2型糖尿病患者的临床症状,改善糖脂代谢、胰岛素分泌,起到血管内皮保护作用。

Objective:To study the protective efficacy of the Qingre Quzhuo capsules(清热祛浊胶囊)on endothelial function in patients with T2DN of the Tanshi Yure type(痰湿郁热型).Methods:60 patients with T2DN were randomly divided into the control group and Qingre Quzhuo capsules group,30 cases in each group.All the patients in the two groups were given basic treatments such as diet prescription control,health educationand individualized exercise guidance according to individual conditions.The control group was treated with metformin enteric-coated tablets more,and the Qingre Quzhuo capsules group was treated with Qingre Quzhuo capsules more,for 12 weeks.BMI,glucose,HbAlc HOMA-IR,blood lipids,ET-1,NO were observed after 12 weeks,brachial artery blood flow-mediated endothelium-dependent vasodilation was detected by ultrasound,and the main syndromes points were evaluated.Results:Symptoms scores in the Qingre Quzhuo capsules group were lower than the control group.The improvement of BMI,glucose,blood fat and HOMA-IR levels in the Qingre Quzhuo capsules group was better,the level of ET-1 was lower than that in the control group,but the levels of NO and FMD were higher than the control group.Conclusion:The therapy has good effects,is beneficial to reduce the clinical symptoms of the type 2 diabetes mellitus and improve the metabolism of glycolipid,which has good vascular endothelial protection.