健脾益肾补气汤对大肠癌患者术后免疫功能的影响

Effect of Jianpi Yishen Buqi Decoction on Postoperative Immune Function of Patients with Colorectal Cancer

目的:观察健脾益肾补气汤对大肠癌患者术后免疫功能的影响。方法:将本院行根治性手术治疗的64例大肠癌患者按照随机数字表法分为对照组和观察组,每组各32例。对照组术后接受化疗,观察组在对照组的基础上加用健脾益肾补气汤治疗。比较两组患者的临床疗效、不良反应发生情况及治疗前后中医证候积分、免疫细胞因子(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)水平、生活质量评分变化情况。结果:对照组有效率为75.00%,观察组有效率为93.75%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后中医证候积分低于本组治疗前,且观察组治疗后低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后CD3^+、CD4^+、CD4^+/CD8^+水平低于本组治疗前,CD8^+高于本组治疗前,观察组患者治疗后CD3^+、CD4^+、CD4^+/CD8^+水平高于对照组治疗后,CD8^+高于对照组治疗后,差异具有统计学意义(P<0.05)。两组患者治疗后QLQ-C30评分高于本组治疗前,且观察组治疗后高于对照组,差异具有统计学意义(P<0.05)。观察组患者化疗期间白细胞下降、血小板减少、胃肠道反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论:健脾益肾补气汤运用于大肠癌术后,可改善患者免疫功能,提高生活质量,降低化疗导致的不良反应。

Objective:To observe the effect of Jianpi Yishen Buqi Decoction(健脾益肾补气汤,JPYSBQD)on postoperative immune function of patients with colorectal cancer.Method:According to the random number table,64 patients with colorectal cancer were divided into control group and observation group with 32 cases in each group.The control group received postoperative chemotherapy,and the observation group was treated with JPYSBQD on the basis of the control group.The clinical efficacy,adverse reactions,TCM syndrome scores,levels of immune cytokines(CD3^+,CD4^+,CD8^+,CD4^+/CD8^+)and quality of life scores before and after treatment were compared between the two groups.Results:The effective rate was 75.00%in the control group and 93.75%in the observation group.The difference was statistically significant(P<0.05).After treatment,the score of TCM syndrome in the two groups was lower than that before treatment,and that in the observation group was lower than that in the control group,the difference is statistically significant(P<0.05).After treatment,the levels of CD3^+,CD4^+,CD4^+/CD8^+ in the two groups were lower than that before treatment,and CD8^+ was higher than that before treatment,the levels of CD3^+,CD4^+,CD4^+/CD8^+ in the observation group were higher than those in the control group,and CD8^+ was higher than those in the control group,the difference is statistically significant(P<0.05).After treatment,the QLQ-C30 score of the two groups was higher than that before treatment,and that of the observation group was higher than that of the control group,the difference is statistically significant(P<0.05).The incidence of leucopenia,thrombocytopenia and gastrointestinal reaction in the observation group during chemotherapy were significantly lower than that in the control group,the difference is statistically significant(P<0.05).Conclusion:Application of JPYSBQD after colorectal cancer operation can improve the immune function,improve the quality of life and reduce the adverse reactions of chemotherapy.