幽门螺杆菌对6种抗生素的耐药性研究

Study on the resistance of Helicobacter pylori to six antibiotics

目的:探究幽门螺杆菌对6种抗生素的耐药性.方法:选取2017年5月-2018年5月胃镜室就诊患者60例,通过琼脂稀释法检测幽门螺杆菌对抗生素的耐药性.结果:幽门螺杆菌对6种抗生素的耐药率分别是甲硝唑44.72%、克拉霉素24.76%、阿莫西林21.95%、替硝唑21.04%、四环素2.48%以及利福平2.17%;幽门螺杆菌对6种抗生素的耐药性进行对比,差异有统计学意义(P<0.05).结论:联合多种抗生素运用仍然是最佳的抗幽门螺杆菌感染治疗方案,治疗过程中应注意患者体内幽门螺杆菌耐药性变化情况,并依据耐药性变化对治疗方案进行及时有效的调整.

Objective:To study on the resistance of Helicobacter pylori to six antibiotics.Methods:From May 2017 to May 2018,60 patients in gastroscopy room were selected to test the drug resistance of Helicobacter pylori to antibiotics by agar dilution method.Results:The resistance rates of Helicobacter pylori to six antibiotics were metronidazole 44.72%,clarithromycin 24.76%,amoxicillin 21.95%,tinidazole 21.04%,tetracycline 2.48%and rifampin 2.17%;The drug resistance of Helicobacter pylori to six antibiotics was compared,the difference was statistically significant(P<0.05).Conclusion:The combination of multiple antibiotics is still the best treatment for Helicobacter pylori infection,in the course of treatment,we should pay attention to the change of drug resistance of Helicobacter pylori in patients,and adjust the treatment plan timely and effectively according to the change of drug resistance.