吸入异丙托溴铵联合布地奈德治疗哮喘-慢阻肺重叠综合征的效果探讨

Effect of Inhaled Ipratropium Bromide Combined with Budesonide in the Treatment of Asthmatic COPD

目的以哮喘-慢阻肺重叠综合征患者为研究对象,探讨患者应用吸入异丙托溴铵与布地奈德联合治疗的效果。方法以90例哮喘-慢阻肺重叠综合征患者作为本次研究对象并随机分为两组,为对照组(n=45)患者实施布地奈德吸入治疗,为观察组(n=45)患者实施吸入异丙托溴铵与布地奈德联合治疗。结果治疗前患者FEV1、FEV1/FVC等肺功能指标组间差异显著(P>0.05),治疗后观察组患者FEV1、FEV1/FVC均高于对照组(P<0.05)。观察组0级及I级占比高于对照组,III级及IV级占比均低于对照组(P<0.05),两组患者III级占比差异不显著(P>0.05)。结论哮喘-慢阻肺重叠综合征患者采用异丙托溴铵与布地奈德联合吸入治疗能够使其呼吸困难症状得到有效缓解,肺功能改善效果理想。

Objective To investigate the effect of inhaled ipratropium bromide combined with budesonide in patients with asthma-slow lung obstruction syndrome.Methods Ninety patients with asthma-joint obstructive pulmonary overlap syndrome were randomly divided into two groups.The patients in the control group(n=45)were treated with budesonide inhalation for the observation group(n=45).The patient was treated with inhaled ipratropium bromide in combination with budesonide.Results Before the treatment,patients with FEV1,FEV1/FVC and other lung function indicators showed significant differences(P>0.05).After the treatment,patients with FEV1,FEV1/FVC were higher than the control group(P<0.05).The proportion of grade 0 and grade I in the observation group was higher than that in the control group.The proportion of grade III and grade IV was lower than that of the control group(P<0.05).There was no significant difference in the proportion of grade III between the two groups(P>0.05).Conclusion Inhalation therapy with ipratropium bromide and budesonide in patients with asthma-joint lung overlap syndrome can effectively alleviate the symptoms of dyspnea and improve lung function.