摘要
目的建立新的药用玻璃容器中砷、锑、铅、镉浸出量的测定方法。方法采用电感耦合等离子体质谱法同时测定药用玻璃容器中砷、锑、铅、镉的浸出量。四种元素在0~100ng·mL-1范围内线性良好,相关系数r=0.9993~0.9998,检出限为0.001~0.01ng·mL-1,回收率为96%~111%。新建方法符合方法验证要求。结论该法快速高效,灵敏度高,绿色环保,可以作为国家药包材标准YBB00372004-2015中规定检测方法的一种参考方法。
Objective:To establish a new method for determination of As,Sb,Pb,Cd extraction in pharmaceutical glass containers.Method:Simultaneous analysis of As,Sb,Pb,Cdby ICP-MS.The four elements showed good linearity in the range of 0~100ng·mL-1,r=0.9993~0.9998,The detection limit was 0.001~0.01 ng·mL-1,the recovery was 96%~111%.The new method accords with method validation.Conclusion:This method was simple and rapid with high sensitivity,good accuracy and green environmental protection.
作者
景菲
汤云
许珍熙
杨晓慧
Jing Fei;Tang Yun;Xu Zhenxi;Yang Xiaohui(Jiangsu Institute of Medical Device Testing,Jiangsu Nanjing 210022;Institute of Chemical Industry of Forestry Products,Chinese Academy of Forest,Jiangsu Nanjing 210042)
出处
《化工时刊》
CAS
2020年第2期15-16,20,共3页
Chemical Industry Times
基金
江苏省生物质能源与材料重点实验室基本科研业务费项目资助(JSBEM-S-201803)。
关键词
药用玻璃容器
电感耦合等离子体质谱
砷
锑
铅
镉
pharmaceutical glasscontainers
inductively coupled plasma mass spectrometry
As
Sb
Pb
Cd
