不同剂量的阿托伐他汀治疗缺血性脑血管病的效果研究

Effect of Different Doses of Atorvastatin on Ischemic Cerebrovascular Disease

目的探讨在缺血性脑血管病患者中应用不同剂量阿托伐他汀的治疗效果。方法2018年1—12月,从该院住院患者中挑选120例缺血性脑血管病患者作为研究对象,采用随机均匀方法作为分组原则,将研究对象分为对照组(60例)和观察组(60例),两组患者均实施常规治疗,对照组在常规治疗的基础上每天应用20 mg阿托伐他汀治疗,观察组在常规治疗的基础上每天应用40 mg阿托伐他汀治疗,持续治疗3个月后对两组患者的血清学指标改善情况、血脂指标改善情况及颈动脉内膜中层厚度改善情况进行比较分析。结果对照组与观察组治疗后C反应蛋白、同型半胱氨酸为(10.99±2.66)μmol/L、(15.69±2.58)μmol/L;(8.03±2.06)μmol/L、(12.03±2.16)μmol/L,治疗后两组患者的血清学指标均有所降低,观察组患者的血清学指标均低于对照组,差异有统计学意义(t=4.263、4.236,P<0.05)。对照组与观察组颈动脉内膜中层厚度治疗后分别为(1.26±0.23)mm、(1.03±0.19)mm,观察组患者的颈动脉内膜中层厚度均薄于对照组,差异有统计学意义(t=4.261,P<0.05)。结论在缺血性脑血管病患者中,应用40 mg阿托伐他汀治疗的效果优于20 mg阿托伐他汀,改善了患者的临床状况,值得推广应用。

Objective To investigate the therapeutic effects of different doses of atorvastatin in patients with ischemic cerebrovascular disease.Methods From January to December 2018,120 patients with ischemic cerebrovascular disease were selected from the inpatients in the hospital.The randomized uniform method was used as the grouping principle.The subjects were divided into control group(60 cases)and observation group(60 cases),both groups of patients were treated with conventional treatment.The control group was treated with 20 mg of atorvastatin daily on the basis of conventional treatment.The observation group was treated with 40 mg of atorvastatin per day on the basis of conventional treatment,and after 3 months of treatment,the improvement of serum indicators,improvement of blood lipid index and improvement of carotid intima-media thickness were compared between the two groups.Results After treatment,the C-reactive protein and homocysteine in the control group and the observation group were(10.99±2.66)μmol/L,(15.69±2.58)μmol/L;(8.03±2.06)μmol/L,(12.03±2.16)μmol/L.The serum indexes of the two groups were decreased after treatment.Comparative analysis showed that the serum scores of the observation group were lower than those of the control group,the difference was statistically significant(t=4.263,4.236,P<0.05).The carotid intima-media thickness of the control group and the observation group were(1.26±0.23)mm and(1.03±0.19)mm.The carotid intima-media thickness of the observation group was thinner than that of the control group,the difference was statistically significant(t=4.261,P<0.05).Conclusion In patients with ischemic cerebrovascular disease,40 mg of atorvastatin is better than 20 mg of atorvastatin,which improves the clinical status of patients and is worthy of promotion.