新型冠状病毒肺炎疫情下的结直肠癌患者化疗策略

Chemotherapy strategy for colorectal cancer under the outbreak of corona virus disease 2019

新型冠状病毒肺炎疫情的爆发给结直肠癌的治疗带来了困难。肿瘤患者作为感染的高危人群,肿瘤病史作为新冠肺炎不良预后的重要因素,都是当下医患双方共同面临的挑战。对于复发转移性结直肠癌患者,低强度的维持治疗是更好的选择,病情变化或恶性度较高的肿瘤患者仍需接受联合化疗。对于根治术后的患者,鉴于辅助化疗获益程度的相对有限,可降低治疗强度并减少治疗时间。面对发热的肿瘤化疗患者,需要对患者的发热原因进行分析,按国家《新型冠状病毒感染的肺炎诊疗方案(试行第六版)》文件规定的流程接受排查。病情稳定、一般状况良好及治疗有效的患者可择期推迟影像学评估的时间。临床医师应根据每例患者的具体情况作出个体化的临床决策。

The outbreak of corona virus disease 2019(COVID-19)makes the medical treatment of colorectal cancers difficult.Cancer patients are more susceptible to infection and tumor history is defined as an important factor of poor prognosis,which challenges both doctors and patients.For metastatic colorectal cancer(CRC)patients,maintenance therapy is the optimal choice.The patients with tumor progression or poor biological behavior should receive or continue combination chemotherapy.Adjuvant chemotherapy should reduce the intensity of treatment and shorten the therapy time.Fever patients during chemotherapy need to receive differential diagnosis and screening according to national standards.Patients with stable diseases and good general conditions may delay imaging examination.Clinicians should make individual clinical decisions based on the specifics of each patient during epidemic situation.