穿琥宁注射液治疗慢性阻塞性肺病急性加重期效果及对IL-8、hs-CRP、TNF-α水平的影响

Efficacy of Chuanhuning injection in treatment of acute exacerbation of chronicobstructive pulmonary disease and effect to IL-8, hs-CRP and TNF-α

目的观察穿琥宁注射液治疗慢性阻塞性肺病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)的效果及对白细胞介素8(interleukin-8,IL-8)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、血清肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)水平影响。方法选取AECOPD患者100例随机分为对照组和治疗组各50例。对照组给予常规治疗,治疗组在对照组基础上静脉滴注500 mg穿琥宁注射液,2组疗程均为14 d。比较治疗前后2组中医症候评分、临床疗效、肺功能以及血清hs-CPR、IL-8和TNF-α水平的差异。结果治疗组治疗有效率明显高于对照组(P<0.05)。2组血清hs-CPR、IL-8和TNF-α水平均呈逐渐下降趋势,且治疗组下降更明显,其组间、时点间、组间·时点间交互作用差异均有统计学意义(P<0.01)。2组1秒用力呼气容积(forced expiratory volume in one second,FEV 1)、用力肺活量(forced vital capacity,FVC)和FEV 1/FVC水平均呈逐渐上升趋势,且治疗组上升更明显,其组间、时点间、组间·时点间交互作用差异均有统计学意义(P<0.01)。与治疗前比较,2组治疗后咳痰、咳嗽、啰音和喘息评分均明显降低,且治疗后治疗组显著低于对照组(P<0.01)。结论采用穿琥宁注射液治疗AECOPD,具有较好的临床效果,能够明显降低hs-CPR、IL-8和TNF-α水平,值得在临床推广应用。

Objective To study effects of Chuanhuning injection in treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and the efficacy of interleukin 8(IL-8),hypersensitive C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)level.Methods One hundred patients with AECOPD were randomly divided into two groups:control group and treatment group.The patients in the control group were given routine treatment,while the patients in the treatment group were given 500 mg Chuanhuning injection on the basis of the control group.The differences of TCM syndrome score,clinical effect,lung function and serum hs-CPR,IL-8 and TNF-αlevels between the two groups before and after treatment were compared.Results After treatment,the effective rate of treatment in the treatment group was significantly higher than that in the control group(P<0.05).The serum levels of hs-CPR,IL-8 and TNF-αin the two groups showed a gradual downward trend,and the decline in the treatment group was more obvious,and the differences in the interaction among groups,time points and groups were statistically significant(P<0.05).The level of forced expiratory volume in one second(FEV 1),forced vital capacity(FVC)and FEV 1/FVC in the two groups increased gradually,and the level of FEV 1/FVC in the treatment group increased more significantly,the difference of interaction among groups,time points and groups was statistically significant(P<0.05).After treatment,compared with before treatment,the scores of expectoration,cough,rale and wheeze in the two groups were significantly lower,and the scores in the treatment group were significantly lower than control group(P<0.01).Conclusion Chuanhuning injection has a good clinical effect in the treatment of AECOPD,which can significantly reduce the levels of hs-CPR,IL-8 and TNF-α.It is worthy of clinical application.