经鼻持续气道正压通气联合3%高渗盐水雾化吸入治疗重度毛细支气管炎的临床效果

Clinical effect of nasal continuous positive airway ventilation combined with 3%hypertonic saline aerosol inhalation in the treatment of severe bronchiolitis

目的探讨经鼻持续气道正压通气联合3%高渗盐水雾化吸入治疗重度毛细支气管炎的临床效果。方法将重症毛细支气管炎患儿按电子病历随机排序,抽取患儿106例随机分为观察组和对照组各53例。2组患者中喘憋症状严重者在常规治疗基础上均优先给予鼻持续气道正压通气。观察组在上述治疗基础上雾化吸入3%高渗盐水。于入院时和治疗24,48,72 h时比较2组病情严重程度评分,比较2组住院时间和不良反应发生情况。结果组患儿病情严重程度评分均呈降低趋势,观察组病情严重程度评分降低幅度较大,组间、时点间、组间·时点间交互作用差异有统计学意义(P<0.05或P<0.01)。观察组住院时间短于对照组。2组均无明显不良反应发生。结论经鼻持续气道正压通气联合3%高渗盐水雾化吸入治疗重度毛细支气管炎临床效果显著,可改善疾病转归,降低不良反应发生率,值得临床推广应用。

Objective To investigate the clinical effect of nasal continuous positive airway pressure ventilation combined with 3%hypertonic saline aerosol inhalation in the treatment of severe bronchiolitis.Methods Children(106 patients)with severe bronchiolitis were sorted according to the electronic medical records.These children were randomly divided into observation group and control group,with 53 cases in each group.On the basis of routine treatment,nasal continuous positive airway pressure ventilation was given priority in both groups for patients who suffered from dyspnea,and inhalation of 3%hypertonic saline by atomization was given to the observation group.At the time of admission and 24,48,72 hours after treatment,the severity scores,hospitalization time and adverse reactions were respectively compared between the two groups.Results The severity scores of both groups showed a decreasing trend,and the score of the observation group decreased significantly.There were significant differences for the severity scores between groups,time point after treatment and the interaction of groups and time points(P<0.05 or P<0.01).The hospital stay of the observation group was shorter than that of the control group,and no significant adverse reactions occurred in the both groups.Conclusion 3%hypertonic saline aerosol inhalation combined with nasal continuous positive airway pressure ventilation in the treatment of severe bronchiolitis has significant clinical effect,improves the prognosis of the disease,and reduces the incidence of adverse reactions,which is worthy of clinical application.