脑血管病常规药物联合SSRI类抗抑郁药物治疗脑卒中后抑郁的疗效分析

The Value Analysis of Conventional Drugs for Cerebrovascular Disease and SSRI Antidepressants in the Treatment of Post-stroke Depression

目的分析脑血管病常规药物联合5-羟色胺再摄取抑制剂(SSRI)类抗抑郁药物治疗脑卒中后抑郁的价值。方法选取2015年3月—2017年3月我院收治的脑卒中后抑郁病人150例为研究对象,按照随机数字表法均分成对照组和研究组,各75例。对照组给予脑血管病常规药物治疗,研究组则给予脑血管病常规药物联合SSRI类抗抑郁药物治疗。比较两组临床疗效、汉密尔顿抑郁量表(HAMD)评分、认知功能量表(MMSE)评分、Barthel指数以及不良反应发生情况等。结果研究组治疗总有效率为88.00%,明显高于对照组的72.00%(P<0.05)。治疗后研究组与对照组HAMD评分均明显低于治疗前,且研究组明显低于对照组(P<0.05)。治疗后研究组MMSE评分、Barthel指数评分分别为(29.15±6.81)分、(86.33±11.48)分,均明显高于对照组的(24.97±6.20)分、(75.01±12.05)分,差异有统计学意义(P<0.05)。研究组恶心呕吐、头晕以及口干发生率与对照组相比差异无统计学意义(P>0.05)。结论脑血管病常规药物联合SSRI类抗抑郁药物治疗脑卒中后抑郁疗效明显,可有效促进病人神经功能与生活能力的恢复。

Objective To study the value of conventional drugs for cerebrovascular disease and antidepressant drug selective serotonine reuptake inhibitors(SSRI)in the treatment of post-stroke depression.Methods One hundred and fifty patients with post-stroke depression from March 2015 to March 2017 were randomly divided into two groups:the control group(n=75)treated with conventional drugs for cerebrovascular disease,and the study group(n=75)treated with conventional drugs for cerebrovascular disease and SSRI.The clinical efficacy,the Hamilton Depression Scale(HAMD)score,the Mini Mental State Examination(MMSE)score,the Barthel index,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment was 88.00%in the study group,which was significantly higher than that in the control group(72.00%,P<0.05).After treatment,the HAMD scores in the two groups were significantly lower than that before the treatment,which was significantly lower in the study group than that in the control group(both P<0.05).After treatment,the MMSE score and Barthel index(29.15±6.81)and(86.33±11.48)in the study group,were significantly higher than that in the control group[(24.97±6.20)and(75.01±12.05)].The differences were statistically significant(P<0.05).There was no difference in the incidence of nausea,vomiting,dizziness,and dry mouth between two groups(P>0.05).Conclusion Conventional drugs for cerebrovascular disease and SSRI can effectively promote the recovery of neurological function and life ability in patients with post-stroke depression.