丁苯酞胶囊联合银杏达莫注射液治疗老年血管性痴呆的疗效及对认知功能、氧化应激的影响

Efficacy of Butylphthalide Capsule and Ginkgo and Dipyridamole Injection in the Treatment of Senile Vascular Dementia and Its Effect on Cognitive Function and Oxidative Stress

目的研究丁苯酞胶囊联合银杏达莫注射液治疗老年血管性痴呆(VD)疗效及对认知功能、氧化应激的影响。方法采用前瞻性研究方法,选取新乡医学院第三附属医院收治的老年VD病人110例,随机分为对照组和研究组,各55例。对照组给予银杏达莫注射液治疗,在此基础上,研究组加用丁苯酞胶囊治疗,两组均连续治疗2个月。比较两组病人治疗效果、不良反应,同时检测两组治疗前后生活质量、认知功能、血液流变学指标及氧化应激指标。结果研究组治疗总有效率(90.81%)明显高于对照组(74.55%,χ^2=5.15,P=0.02);治疗后,研究组氧化应激过氧化脂质(LPO)、丙二醛(MDA)水平明显高于对照组,而超氧化物歧化酶(SOD)活力水平则明显高于对照组(P<0.01);研究组血液流变学纤维蛋白原(PF)、血浆黏度(PV)、全血高切黏度(HBV)、全血低切黏度(LBV)均明显低于对照组(P<0.01);研究组简易精神状态量表(MMSE)评分、Barthel指数(BI)评分均明显高于对照组(P<0.01);同时,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论丁苯酞胶囊联合银杏达莫注射液可明显改善老年VD病人机体氧化应激反应及脑血流动力学指标,有利于优化病人生活质量及认知功能,疗效显著且安全可靠。

Objective To study the efficacy of Butylphthalide capsule and Ginkgo and Dipyridamole injection(GDI)in the treatment of senile vascular dementia(VD)and its effect on cognitive function and oxidative stress.Methods A prospective study was conducted.One hundred and ten patients with senile VD were randomly divided into two groups:the control group(n=55)treated with GDI,and the study group(n=55)treated with Butylphthalide capsule and GDI for 2 months.The therapeutic effects and adverse reactions were compared between the two groups.The quality of life,cognitive function,hemorheology and oxidative stress were compared between the two groups before and after treatment.Results The total effective rate of treatment was 90.81%in the study group,which was significantly higher than that in the control group(74.55%,χ^2=5.15,P=0.02).After treatment,the levels of lipid peroxidation(LPO)and malondialdehyde(MDA)in the study group were significantly lower than those in the control group,while the levels of superoxide dismutase(SOD)activity were significantly lower than those in the control group(P<0.01).The levels of PF,plasma viscosity(PV),whole blood high blood viscosity(HBV),and whole blood low blood viscosity(LBV)were significantly lower in the study group than in the control group(P<0.01).The scores of Mini Mental State Scale(MMSE)and Barthel Index(BI)in the study group were significantly higher than those in the control group(P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Butylphthalide capsule and GDI can significantly improve the oxidative stress response and cerebral hemodynamics in patients with senile VD,which helpful to optimizing their quality of life and cognitive function.