乌司他丁联合生长抑素治疗急性胰腺炎的效果

Effect of Ulinastatin combined with Somatostatin in the treatment of acute pancreatitis

目的探讨急诊应用乌司他丁联合生长抑素治疗急性胰腺炎的效果。方法选取2017年1月~2019年1月我院收治的60例急性胰腺炎患者作为研究对象,根据随机数字表法分为单药物治疗组与联合药物治疗组,每组各30例。单药物治疗组采取生长抑素治疗,联合药物治疗组采取生长抑素+乌司他丁治疗。比较两组的治疗效果;比较两组的血淀粉酶恢复正常时间、尿淀粉酶恢复正常时间、住院时间、治疗前后患者急性生理与慢性健康评分(APACHEⅡ)、尿淀粉酶监测水平、血淀粉酶监测水平、白介素-6、肿瘤坏死因子-α、不良反应发生率。结果联合药物治疗组治疗总有效率高于单药物治疗组,差异有统计学意义(P<0.05);联合药物治疗组血淀粉酶恢复正常、尿淀粉酶恢复正常、住院时间短于单药物治疗组,差异有统计学意义(P<0.05);联合药物治疗组APACHEⅡ评分、尿淀粉酶监测水平、血淀粉酶监测水平、白介素-6、肿瘤坏死因子-α低于单药物治疗组,差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论生长抑素+乌司他丁治疗胰腺炎效果好,可改善血尿淀粉酶,控制炎症,加速康复,缩短治疗时间。

Objective To explore the effect of Ulinastatin combined with Somatostatin in the treatment of acute pancreatitis in emergency.Methods Sixty patients with acute pancreatitis admitted to our hospital from January 2017 to January 2019 were enrolled in the study.According to the random number table method,they were divided into drug alone treatment group and combined drug treatment group,30 cases in each group.The drug alone group was treated with Somatostatin,and the combined group was treated with Somatostatin+Ulinastatin.The therapeutic effects on pancreatitis including the time of blood amylase to return to normal range,the time of urinary amylase to return to normal range,hospital stay,acute and chronic health scores(APACHEⅡ),urine amylase monitoring level before and after treatment,blood amylase monitoring level,interleukin-6,tumor necrosis factor-α,and adverse reactions in the two groups were compared.Results The total effectiveness rate of the combined drug group was higher than that of the drug alone group,and the difference was statistically significant(P<0.05).The time when the blood amylase returned to the normal range,the time when the urinary amylase returned to the normal range and the hospital stay in the combined drug group were shorter than those in the drug alone group,the difference were statistical singificant(P<0.05).The APACHEⅡscore,urine amylase monitoring,blood amylase monitoring,interleukin-6 and tumor necrosis factor-αin the combined drug group were lower than those in the drug alone group,the difference were statistical singificant(P<0.05).There was no statistical difference in the overall incidence of adverse reactions between the two groups(P>0.05).Conclusion Application of Somatostatin+Ulinastatin is effective in the treatment of pancreatitis,which can improve blood urea gelatinase,control inflammation,facilitate recovery and shorten treatment time.