矮小症儿童骨密度与血清维生素A、D、K水平的关系

Relationship between bone mineral density and serum vitamin A, D and K levels in children with dwarfism

目的分析矮小症儿童骨密度与血清维生素A、D、K水平的关系。方法选取2016年1月~2017年9月在我院咨询并治疗的73例矮小症患儿和同年龄、性别的73例正常儿童分别作为病例组和对照组,分别检测病例组和对照组儿童的身高、体重、骨密度及血清维生素A、D、K水平。将病例组儿童根据骨密度Z值分为骨密度轻度不足组(27例)、骨密度中度不足组(35例)和骨密度严重不足组(11例),分析病例组患儿骨密度、年龄分别与血清维生素A、D、K水平的关系。结果病例组的身高、体重、骨密度值及维生素A、D、K水平均低于对照组,差异有统计学意义(P<0.05)。骨密度中度不足组和骨密度重度不足组的血清维生素D、K水平均低于骨密度轻度不足组,差异有统计学意义(P<0.05);骨密度重度不足组的血清维生素D、K水平均低于骨密度中度不足组,差异有统计学意义(P<0.05);不同骨密度不足患儿的血清维生素A水平比较,差异无统计学意义(P>0.05)。血清维生素D、K与骨密度成中等正相关(r=0.677、0.659,P<0.05),血清维生素D、K与年龄成中等正相关(r=0.549,0.518,P<0.05)。结论血清维生素D和维生素K水平与矮小症儿童骨密度高低有关,早期检测对预防和减少矮小症儿童低骨密度发生有重要价值。

Objective To analyze the relationship between bone mineral density and serum vitamin A,D and K levels in children with dwarfism.Methods A total of 73 children with dwarfism consulted and treated in our hospital and 73 normal children with the same age and gender from January 2016 to September 2017 were selected as the case group and the control group respectively,and the height,weight,bone mineral density and serum vitamin A,D and K levels of the children in two groups were measured.The children in the case group were divided into mild bone mineral density deficiency group(27 cases),moderate bone mineral density deficiency group(35 cases)and severe bone mineral density deficiency group(11 cases)according to the bone mineral density Z values,and the relationship between bone mineral density,age and serum vitamin A,D and K levels in the case group was analyzed.Results The height,weight,bone mineral density and vitamin A,D and K levels in the case group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of serum vitamin D and K in the moderate bone mineral density deficiency group and the severe bone mineral density deficiency group were lower than those in the mild bone mineral density deficiency group,and the differences were statistically significant(P<0.05).The levels of serum vitamin D and K in the severe bone mineral density deficiency group were lower than those in the moderate bone mineral density deficiency group,and the differences were statistically significant(P<0.05).There were no significant differences in serum vitamin A levels in the children with different bone mineral density deficiency(P>0.05).Serum vitamin D and K were moderately positively correlated with bone mineral density(r=0.677,0.659,P<0.05),and serum vitamin D and K were moderately positively correlated with age(r=0.549,0.518,P<0.05).Conclusion Serum vitamin D and vitamin K levels are associated with the bone mineral density in children with dwarfism,the early detection is of great value for the prevention and reduction of low bone mineral density in children with dwarfism.