临床药师处方审核对静脉配置中心抗肿瘤药物不合理医嘱干预效果分析

Intervention effect analysis of clinical pharmacist reviewing on the unreasonable medical prescriptions of anti-tumor drugs in the vein configuration center

目的分析临床药师处方审核对静脉配置中心抗肿瘤药物不合理医嘱干预效果。方法经过临床药物系统与医院信息系统(HIS)回顾性分析2018年1~6月本院住院患者的抗肿瘤药物静脉用药医嘱,统计患者不合理用药状况,作为干预前资料;2018年7~12月临床药师参与医嘱审核,对不合理医嘱进行干预,统计患者不合理用药状况,作为干预后资料。将本院全年得到的数据行统计学分析,比较干预前后抗肿瘤药物的不合理医嘱改变状况和药师干预效果。结果干预后的不合理医嘱率为3.28%,低于干预前的8.78%,差异有统计学意义(P<0.05);干预前后妇科、耳鼻喉科、肿瘤科、肝胆肠胃外科、胸外科不合理医嘱率比较,差异均有统计学意义(P<0.05);干预前后放疗科及其他不合理医嘱率比较,差异无统计学意义(P>0.05)。结论不同科室均存在不同程度的不合理医嘱情况,经临床药师干预可有效降低抗肿瘤药物不合理医嘱发生率,避免或减少药物不良反应的发生。

Objective To analyze the intervention effect of clinical pharmacist reviewing on the unreasonable medical prescriptions of anti-tumor drugs in the vein configuration center.Methods The clinical drug system and hospital information system(HIS)were retrospectively analyzed.The anti-tumor drugs for inpatients in our hospital from January to June in 2018 were used to calculate the irrational use of drugs,as data before intervention.From July to December in 2018,clinical pharmacists participated in the medical reviewing,intervened when there were unreasonable medical prescriptions,and recorded the irrational use of drugs as data after intervention.The data obtained in the hospital throughout the year were statistically analyzed to compare the unreasonable medical prescriptions change of anti-tumor drugs before and after intervention and the effect of pharmacist intervention.Results The unreasonable rate of medical prescription after intervention was 3.28%,which was lower than 8.78%before intervention,with statistically significant difference(P<0.05).There were statistically significant differences in the unreasonable rates of medical prescriptions of gynecology,otolaryngology,oncology,hepatobiliary gastrointestinal surgery,and thoracic surgery departments before and after intervention(P<0.05).There were no significant differences in the unreasonable rates of medical prescriptions of radiotherapy and other departments before and after intervention(P>0.05).Conclusion There are varied degrees of unreasonable medical prescriptions in different departments.Intervention by clinical pharmacists can effectively reduce the incidence of unreasonable anti-tumor drugs and avoid or reduce the incidence of adverse drug reactions.