万古霉素治疗革兰阳性球菌感染重症肺炎的临床效果

Clinical effect of Vancomycin in the treatment of severe pneumonia infected by Gram-positive cocci

目的研究万古霉素治疗革兰阳性球菌感染重症肺炎的临床效果。方法选取2016年4月~2019年3月我院收治的80例革兰阳性球菌感染的重症肺炎患者作为研究对象,按照随机数字表法分为对照组和观察组,每组各40例。对照组采用左氧氟沙星治疗,观察组采用万古霉素治疗,比较两组患者的治疗效果、细菌清除率、治疗后产生的不良反应情况。结果观察组患者的治疗总有效率为95.00%,高于对照组的75.00%,差异有统计学意义(P<0.05);观观察组患者的细菌总清除率为95.00%,高于对照组的75.00%,差异有统计学意义(P<0.05);观察组患者的不良反应总发生率为5.00%,低于对照组的22.50%,差异有统计学意义(P<0.05)。结论万古霉素治疗革兰阳性球菌感染的重症肺炎的效果显著,安全有效,不良反应少。

Objective To study the clinical effect of Vancomycin in the treatment of severe pneumonia infected by Gram-positive cocci.Methods Eighty patients with severe pneumonia infected by Gram-positive cocci treated in our hospital from April 2016 to March 2019 were selected as the study subjects.The patients were divided into the control group and the observation group according to the random number table method,with 40 cases in each group.Patients in the control group were treated with Levofloxacin,and in the observation group,patients were treated with Vancomycin.The therapeutic effects,bacterial clearance rate,and adverse reactions in two groups after treatment were compared.Results The total effective rate of the observation group was 95.00%,which was higher than that of the control group accounting for 75.00%,and the difference was statistically significant(P<0.05).The total bacterial clearance rate of the observation group was 95.00%,which was higher than that of the control group accounting for 75.00%,with statistical significance(P<0.05).The total incidence of adverse reactions in the observation group was 5.00%,which was lower than that in the control group accounting for 22.5%,with statistical significance(P<0.05).Conclusion Vancomycin is effective in the treatment of severe pneumonia caused by gram-positive cocci.It is safe and effective,which has less adverse reactions.