基于数据挖掘的刘丽芳教授治疗乳腺导管瘘用药处方规律分析

Research on Professor LIU Lifang’s Medication Rules in the Treatment of Mammary Ductal Fistula Based on Data Mining

目的分析刘丽芳教授治疗乳腺导管瘘的临床用药配伍规律。方法整理收集刘丽芳教授治疗乳腺导管瘘2011年1月至2017年6月的门诊处方,运用“中医传承辅助平台(v2.5)”软件进行数据挖掘,对所选处方用药频次、药物关联规则、组方规律、核心处方、新处方进行分析。结果共纳入处方3723首,高频药物组合54组,出现频率最高的为“蒲公英-白术”、“蒲公英-金银花(济银花)”。确定药物之间关联规则,进行统计分析后获得药物核心组合20个,得到新处方10个。结论刘丽芳教授治疗乳腺导管瘘以清热解毒、消肿散结为核心治则,注重疏肝和胃,并结合甘苦合化法,化痰燥湿、行气活血等治法分期论治。

Objective To analyze Professor LIU Lifang's clinical medication and compatibility rule in the treatment of mammary ductal fistula.Methods The outpatient prescriptions of Professor LIU Lifang for mammary ductal fistula from January 2011 to June 2017 were collected.Data mining was carried out by using the software of"Traditional Chinese Medicine Inheritance Assistance Platform(v2.5)",and the frequency of drug use,drug association rules,prescription rules,core prescriptions and new prescriptions were analyzed.Results A total of 3723 prescriptions were included and 54 high frequency drug combinations were obtained.The highest frequencies were"Herba Taraxaci-Rhizoma Atractylodis Macrocephalae"and"Herba Taraxaci-Flos Lonicerae".The drug association rules were determined.After statistical analysis,20 core drug combinations and 10 new prescriptions were obtained.Conclusion Professor LIU Lifang's treatment of mammary ductal fistula is taking clearing heat,detoxification,detumescence and dispersing knots as core treatment principles.He pays attention to soothing the liver and harmonizing stomach,and combines the treatment methods of bitterness and sweetness,resolving phlegm and drying dampness,promoting Qi and activating blood circulation for treatment at different periods.