普拉克索联合复方左旋多巴对帕金森病患者运动功能及非运动症状的影响

Effect of Pramipexole combined with Compoud Levodopa on motor function and non-motor symptoms in patients with Parkinson′s disease

目的探讨普拉克索联合复方左旋多巴对帕金森病(PD)患者运动功能及非运动症状的影响。方法选取2017年6月~2019年5月大连市第三人民医院收治的96例PD患者作为研究对象,按随机数字表法分为观察组和对照组,每组各48例。对照组接受复方左旋多巴治疗,观察组接受复方左旋多巴联合普拉克索治疗,均治疗16周。比较两组的统一帕金森病量表(UPDRS)Ⅲ评分、汉密尔顿抑郁量表(HAMD)评分、非运动症状及不良反应总发生率。结果治疗前,两组的UPDRSⅢ、HAMD评分及尿频尿急、感觉异常、睡眠障碍、流涎、便秘发生率比较,差异无统计学意义(P>0.05);治疗后,观察组的UPDRSⅢ、HAMD评分及尿频尿急、感觉异常、睡眠障碍发生率均低于对照组,差异有统计学意义(P<0.05);观察组的不良反应总发生率为6.25%,低于对照组的20.83%,差异有统计学意义(P<0.05)。结论PD患者接受普拉克索联合复方左旋多巴治疗,能缓解患者的焦虑程度,降低患者的非运动症状发生率和不良反应发生率,值得临床推广应用。

Objective To investigate the effect of Pramipexole combined with Compoud Levodopa on motor function and non-motor symptoms in patients with Parkinson′s disease(PD).Methods A total of 96 patients with PD admitted to the Third People′s Hospital of Dalian from June 2017 to May 2019 were selected as the research objects,they were divided into observation group and control group according to the random number table method,with 48 cases in each group.The control group received Compound Levodopa,the observation group received Compound Levodopa combined with Pramipexole,both for 16 weeks.The united Parkinson′s disease scale(UPDRS)Ⅲ,hamilton depression scale(HAMD),non motor symptoms and the total incidence of adverse reactions were compared between the two groups.Results Before treatment,there were no significant differences in UPDRSⅢ,HAMD scores,frequency of urination,urgency of urination,abnormal sensation,sleep disorder,salivation and constipation between the two groups(P>0.05).After treatment,the scores of UPDRSⅢ,HAMD,frequency of urination,urgency of urination,abnormal sensation and sleep disorder in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was 6.25%,which was lower than 20.83%in the control group,the difference was statistically significant(P<0.05).Conclusion Pramipexole combined with Compound Levodopa can relieve anxiety of PD patients,reduce the incidence of non motor symptoms and adverse reactions,which is worthy of clinical application.