血清C反应蛋白与降钙素原检测在诊断血液病合并细菌感染中的应用价值

Application value of serum C-reactive protein and procalcitonin in diagnosis of hematological diseases complicated with bacterial infection

目的探讨血清C反应蛋白(CRP)与降钙素原(PCT)检测在诊断血液病合并细菌感染中的应用价值。方法选取2016年10月~2018年10月本院收治的90例血液病患者,依据病原体检查结果分为合并细菌感染组(n=43例)和非细菌感染组(n=47例),另外选取同期到本院行健康体检的健康者45例作为对照组,采取三组入选者清晨空腹状态下5 ml肘静脉血,离心取血清后,测定血清CRP、PCT水平,分析CRP、PCT诊断血液病合并细菌感染、非细菌感染阳性检出率、特异度、灵敏度及准确度。结果三组中,细菌感染组血清CRP、PCT水平最高,其次是非细菌感染组,对照组血清CRP、PCT水平最低,差异有统计学意义(P<0.05);血清PCT诊断细菌感染的特异度(85.11%)、灵敏度(93.02%)、准确度(88.89%)均高于血清CRP(68.09%、60.47%、64.44%),差异有统计学意义(P<0.05)。结论血清CRP、PCT在诊断血液病合并细菌感染中具有重要价值,且PCT诊断效能高于CRP,利于提升细菌感染检出率。

Objective To explore the application value of serum C-reactive protein(CRP)and procalcitonin(PCT)in the diagnosis of hematological diseases complicated with bacterial infection.Methods Ninety patients with hematological diseases admitted to our hospital from October 2016 to October 2018 were selected and divided into bacterial infection group(n=43)and non-bacterial infection group(n=47)according to the results of pathogenic examination.Forty-five healthy people who came to our hospital for health examination at the same time were selected as control group.The blood samples of elbow vein in 5 ml in fasting state of three groups were collected in the morning and determined after centrifugation.Serum CRP and PCT levels were analyzed.The positive detection rate,specificity,sensitivity and accuracy of CRP and PCT in diagnosis of hematological diseases complicated with bacterial infection and non-bacterial infection were analyzed.Results Among the three groups,the serum CRP and PCT levels were the highest in the bacterial infection group,followed by the non-bacterial infection group,and the lowest in the control group,the difference was statistically significant(P<0.05).The specificity(85.11%),sensitivity(93.02%)and accuracy(88.89%)of CRP were higher than those of CRP(68.09%,60.47%and 64.44%)with statistical significance(P<0.05).Conclusion Serum CRP and PCT are of great value in the diagnosis of hematological diseases complicated with bacterial infections,and PCT is more effective than CRP in the diagnosis of bacterial infections,which is conducive to improving the detection rate of bacterial infections.