中药抗巨噬细胞泡沫化有效成分研究概况

Overview of Research on Effective Components Against Formation of Macrophage Foam Cells in Chinese Materia Medica

动脉粥样硬化(AS)是多因素互为影响的病理生理过程,其中巨噬细胞泡沫化是其发生发展的关键一步。许多中药被证实具有调节血脂的作用,汇总了中药中抗巨噬细胞泡沫化的有效成分,从中药多靶点、多途径的作用特点方面综述了中药材中蒽醌类、多糖类、皂苷类、多酚类、生物碱类、不饱和脂肪酸类、黄酮类、蛋白质类等有效成分抗巨噬细胞泡沫化的作用机制和途径,为动脉粥样硬化的预防和治疗带来更多启示。参考文献31篇。

Atherosclerosis(AS) is a pathophysiological process,during which multiple factors interact with each other. Among them,the formation of macrophage foam cells is a key step in its occurrence and development. It has been confirmed that many Chinese materia medica play a role in regulating blood fat. This paper summarizes the effective components against the formation of macrophage foam cells in Chinese materia medica and reviews the mechanism and ways through which the effective components such as anthraquinones,polysaccharide,saponins,polypjenols,alkaloids,unsaturated fatty acids,flavonoids and proteins inhibit the formation of macrophage foam cells,showing the multitargeted and multipath characteristics,so as to enlighten the prevention and treatment of AS. There are 31 references.