甲状旁腺素、25-羟维生素D及血清钙磷与原发性骨质疏松症的相关性分析

Correlation between parathyroid hormone,25-hydroxyvitamin D and calcium and primary osteoporosis

目的分析原发性骨质疏松症患者血清钙、磷、甲状旁腺激素(PTH)和25-羟维生素D水平,分析原发性骨质疏松症发生的主要危险因素,并探讨PTH水平与性别和年龄的关系。方法将2017年1月至2018年12月就诊于该院并确诊为原发性骨质疏松症的患者254例纳入研究作为病例组。另外,将同期于该院体检中心体检合格的健康体检者254例纳入研究作为对照组。比较两组生化指标,并进行Logistic回归分析。将2018年6-7月于该院体检中心体检合格的健康体检者2551例纳入研究作为健康人群,分析PTH水平与性别、年龄的关系。结果健康人群PTH水平与性别、年龄均无关(P>0.05)。病例组PTH水平高于对照组(P<0.001),病例组血清钙、磷及25-羟维生素D水平均低于对照组(P<0.001)。Logistic回归分析显示,PTH升高是导致原发性骨质疏松症的主要危险因素,OR值为1.495(95%CI:1.310~1.707,P<0.001)。结论健康人群PTH水平与性别和年龄无关。PTH升高是导致原发性骨质疏松症发生的主要危险因素。

Objective To determine the levels of serum calcium(Ca),phosphorus(P),parathyroid hormone(PTH)and 25-hydroxyvitamin D[25-(OH)-VitD]in patients with osteoporosis,and to analyze the main risk factors which cause the onset of osteoporosis.To explore the relationship between PTH levels and gender and age.Methods From January 2017 to February 2018,254 patients were diagnosed with osteoporosis in the hospital.A total of 254 patients in the physical examination center of the hospital in the same period were recruited as the control group.The biochemical indicators of the two groups were compared.Logistic regression analysis was performed.From June 2018 to July 2018,2551 people who passed the healthy examinations in the hospital were enrolled in the study as healthy people,and the relationship between PTH concentration and gender and age was analyzed.Results The PTH concentration in healthy people were not related to gender and age(P>0.05).The PTH concentration in the case group was higher than that in the control group(P<0.001),and the Ca,P and 25-(OH)-VitD levels in the case group were lower than those in the Control group(P<0.001).Logistic regression analysis showed that PTH was the main risk factor for the onset of osteoporosis,with an OR value of 1.495(95%CI:1.310-1.707,P<0.001).Conclusion PTH in healthy people are not related to gender and age.Elevated PTH is a major risk factor for osteoporosis.