血清LDH、TPO水平在血小板减少性疾病患者预后评估中的价值

The value of serum LDH,TPO levels in the prognostic evaluation of patients with thrombocytopenic disease

目的探讨不同乳酸脱氢酶(LDH)、血小板生成素(TPO)水平的血小板减少性疾病患者短期预后情况。方法于2017年4月至2018年4月,采用病例抽样的方法选取该院收治并在该院接受治疗的血小板减少性疾病患者。测定受试者的血清LDH、TPO水平。根据患者LDH水平是否大于总体均值水平,分为高LDH组和低LDH组;根据患者治疗后TPO水平是否大于总体均值,将患者分为高TPO组和低TPO组。预后评估包括临床症状评估及生活质量评估两个部分。结果接受治疗后血小板减少性疾病患者LDH水平比治疗前下降,TPO水平升高,差异均有统计学意义(P<0.05)。治疗前血小板减少性疾病患者的持续性头痛、恶心、呕吐、躯体功能、情绪功能评分均低于治疗后,差异有统计学意义(P<0.05)。高LDH组的持续性头痛、盗汗、身体钝痛感、躯体功能、情绪功能评分低于低LDH组,差异均有统计学意义(P<0.05);低TPO组的发热、盗汗、身体钝痛感、躯体功能、情绪功能、认知功能评分低于高TPO组,差异均有统计学意义(P<0.05)。结论高LDH、低TPO水平的血小板减少性疾病患者短期预后状况相对较差。

Objective To investigate the short-term prognosis of patients with thrombocytopenia with different levels of lactate dehydrogenase(LDH)and thrombopoietin(TPO).Methods From April 2017 to April 2018,patients with thrombocytopenic disease admitted to our hospital and treated in this hospital were selected by case sampling.According to whether the LDH level of patients is greater than the overall mean level,the patients were divided into high-level LDH group and low-level LDH group;similarly,according to whether the TPO level of patients after treatment is greater than the overall mean level,the patients were divided into high-level TPO group and low-level TPO group.The LDH and TPO levels were determined.The prognostic assessment included clinical symptom assessment and quality of life assessment.Results The levels of LDH in thrombocytopenic disease decreased after treatment,and the level of TPO increased,the differences were all significant(P<0.05).The persistent headache,nausea,vomiting,physical function and emotional function scores before treatment were lower than those after treatment,the differences were statistically significant(P<0.05).The high-level LDH group had persistent headache,night sweats,body dull pain,physical function,emotional function scores lower than those in the low-level LDH group,the differences were statistically significant(P<0.05);fever,night sweats,body blunt pain,physical function,emotional function,and cognitive function scores in the low-level TPO group were lower than those in the high-level TPO group,and the differences were statistically significant(P<0.05).Conclusion The short-term prognosis of patients with thrombocytopenic diseases who have high-level LDH and low-level TPO levels were relatively poor.