孕24周前肝功能异常与母婴结局相关性分析

目的探讨孕24周前肝功能异常与母婴结局的相关性.方法采用前瞻性随机对照研究方法,设置两组观察队列.观察队列A:入组孕24周前出现肝功能异常的孕妇为肝功能异常A组;观察队列B:入组孕24周前出现肝功能异常但孕24周后未出现妊娠期并发症的孕妇为肝功能异常B组.随访观察两组母婴结局.结果观察队列A组中,肝功能异常组孕晚期肝功能异常、妊娠期高血压疾病、高脂血症、产后出血、早产、胎儿宫内窘迫发生率均高于对照A组,但新生儿体重较对照A组偏低,差异均有统计学意义(P<0.05).观察队列B组中,肝功能异常组新生儿体重较对照B组偏低,差异有统计学意义(P<0.05).结论孕24周前合并肝功能异常可增加不良妊娠结局的发生率.

Objective To investigate the relationship between abnormal liver function appeared before 24 weeks and pregnancy outcomes.Methods A prospective randomized controlled study was conducted.Two groups of observation cohort were set up.Cohort A:Pregnant women with abnormal liver function appeared before 24 weeks were enrolled as abnormal liver function A Group.Cohort B:Pregnant women with abnormal liver function appeared before 24 weeks and no complications after 24 weeks were enrolled as abnormal liver function B Group.The two cohorts and observed maternal and neonatal outcomes were We followed up.Results Cohort A:The incidence of abnormal liver function in third trimester,hypertensive hypertension disorders of pregnancy,hyperlipidemia,postpartum hemorrhage,premature delivery and fetal distress in abnormal liver function A Group were significantly higher than those of the control group,while neonatal weight was significantly lower than that of the control group(P<0.05).Cohort B:Neonatal weight in abnormal liver function B Group was significantly lower than that of the control group(P<0.05).Conclusion Abnormal liver function appeared before 24 weeks can increase the incidence of adverse pregnancy outcomes.