环氧合酶2及相关microRNA在心力衰竭患者血浆中表达水平研究

Expression of cyclooxygenase-2 and related microRNA in plasma of patientswith heart failure

目的探讨环氧合酶2(COX-2)及相关微小RNA(microRNA)在心力衰竭患者血浆中的表达水平,为心力衰竭患者诊断和治疗提供更多帮助。方法选取我院2018年3月-2019年5月期间收治的60例冠心病合并心力衰竭患者,将其作为本次调查研究的主要观察对象,纳入观察组。同时选取60例冠心病未合并心力衰竭患者,将其作为对照组,对比两组患者COX-2、microRNA水平。结果观察组COX-2水平高于对照组,观察组microRNA下调趋势明显高于对照组,对比差异有统计学意义(P<0.05);观察组与对照组超声心动图检查相关指标左心室射血分数(LVEF)、左室后壁厚度(LVPW)、左室舒张末期内径(LVEDD)水平存在明显差异,对比有统计学意义(P<0.05);观察组和对照组三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、肌酐(Cr)水平对比无明显差异(P>0.05)。结论合并心力衰竭的冠心病患者,其COX-2、microRNA在血浆中呈高表达状态,对评估患者病情具有较大帮助。

Objective To investigate the expression of cyclooxygenase-2(COX-2)and microRNA in plasma of patients with heart failure,and to provide more help for the diagnosis and treatment of heart failure.Methods From March 2018 to May 2019,60 patients with coronary heart disease complicated with heart failure and 60 patients without heart failure were selected as observation group and control group.The levels of COX-2 and microRNA were compared between the two groups.Results The level of COX-2 in the observation group was higher than that in the control group,and the downward trend of microRNA in the observation group was significantly higher than that in the control group(P<0.05);left ventricular ejection fraction(LVEF),left ventricular posterior wall thickness(LVPW)in the observation group and the control group were correlated with echocardiography.There were significant differences in left ventricular end-diastolic diameter(LVEDD)between the observation group and the control group(P<0.05).There were no significant differences in the levels of triglyceride(TG),high density lipoprotein(HDL-C),low density lipoprotein(LDL-C),creatinine(Cr)between the observation group and the control group(P>0.05).Conclusion The expression of COX-2 and microRNA in plasma of patients with CHD complicated with heart failure is high,which is helpful for evaluating patients'condition.