摘要
As a large group of cells in a central nervous system, astrocytes have a great influence on ion and energy metabolism in a nervous system. Disorders of neuronal ion and energy metabolism caused by impaired astrocytes play a key role in the pathogenesis of epilepsy. This paper reviews the existing computational models of epileptogenesis resulting from impaired astrocytes and presents several open perspectives with regard to ion and energy metabolism-induced epileptogenesis in a neuron-astrocyte-capillary coupled model.
As a large group of cells in a central nervous system, astrocytes have a great influence on ion and energy metabolism in a nervous system. Disorders of neuronal ion and energy metabolism caused by impaired astrocytes play a key role in the pathogenesis of epilepsy. This paper reviews the existing computational models of epileptogenesis resulting from impaired astrocytes and presents several open perspectives with regard to ion and energy metabolism-induced epileptogenesis in a neuron-astrocyte-capillary coupled model.
作者
独盟盟
李佳佳
袁治轩
范永晨
吴莹
Meng-Meng Du;Jia-Jia Li;Zhi-Xuan Yuan;Yong-Chen Fan;Ying Wu(State Key Laboratory for Strength and Vibration of Mechanical Structures,Xi’an Jiaotong University,Xi’an 710049,China;School of Aerospace Engineering,Xi’an Jiaotong University,Xi’an 710049,China;National Demonstration Center for Experimental Mechanics Education,Xi’an Jiaotong University,Xi’an 710049,China)
基金
Project supported by the National Natural Science Foundation of China(Grant No.11772242)。
