穴位药透疗法治疗糖尿病性周围神经病变的疗效观察

Efficacy of acupoint-targeted drug penetration therapy with Chinese medicine in treating diabetic peripheral neuropathy

目的:观察中药穴位药透疗法治疗糖尿病性周围神经病变(DPN)患者的临床疗效。方法:纳入98例DPN患者,随机分为观察组和对照组,每组各49例。所有患者均给予常规降糖方案治疗,在此基础上,对照组患者给予硫辛酸注射液静脉滴注治疗,观察组患者给予硫辛酸注射液静脉滴注联合穴位药透治疗,治疗周期均为14 d。评价两组患者的DPN临床疗效,比较两组患者的神经传导速度(NCV)、多伦多临床评分系统(TCSS)评分。结果:治疗后,观察组患者的临床总有效率为89.8%,对照组为73.5%,观察组的疗效优于对照组(P<0.05)。治疗后,两组患者的腓总神经和正中神经的运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)较治疗前均明显增加(P<0.05,P<0.01),且观察组患者的NCV较对照组明显加快(P<0.05)。治疗后,两组患者的TCSS评分较治疗前均降低(P<0.05),且观察组患者的评分低于对照组(P<0.05)。结论:穴位药透疗法联合西药治疗DPN可显著提高临床疗效,改善患者的临床症状和体征,具有临床推广应用的价值。

Objective:To observe the clinical efficacy of acupoint-targeted drug penetration therapy with Chinese medicine in the treatment of diabetic peripheral neuropathy(DPN). Methods:Ninety-eight patients with DPN were included and randomly divided into the observation group and the control group, 49 cases in each group. All the patients were treated with routine therapy to control the blood glucose. Based on above, the patients in the control group were treated with thioctic acid by intravenous injection, and the patients in the observation group were treated with intravenous injection of thioctic acid combined with acupoint-targeted drug penetration therapy. The treatment course was 14 days. The clinical efficacy on DPN was evaluated in the two groups, and the nerve conduction velocity(NCV) and Toronto clinical scoring system(TCSS) scores were compared between the two groups. Results: After treatment, the total clinical effective rates of the observation group and the control group were 89.8% and 73.5% respectively, and the efficacy of the observation group was better than that of the control group(P<0.05). After treatment, the motor nerve conduction velocity(MNCV) and sensory nerve conduction velocity(SNCV) of common peroneal nerve and median nerve were significantly increased in both groups compared with treatment before(P<0.05,P<0.01), and the NCV of the observation group was obviously faster than that of the control group(P<0.05). After treatment, the score of TCSS was decreased in both groups compared with treatment before(P<0.05), and the score of the observation group was lower than that of the control group(P<0.05). Conclusion: Acupoint-targeted drug penetration with Chinese medicine combined with western medicine can significantly enhance the clinical efficacy in the treatment of DPN, and improve the clinical symptoms and signs of patients, which shows the value of further clinical application.