下气活血通腑汤治疗结肠癌术后急性炎症性肠梗阻临床研究

Clinical Study on Xiaqi Huoxue Tongfu Tang for Acute Inflammatory Intestinal Obstruction after Surgery for Colon Cancer

目的:探究下气活血通腑汤治疗结肠癌术后急性炎症性肠梗阻效果及对炎症因子、胃肠功能的影响。方法:将67例结肠癌术后并发急性炎症性肠梗阻患者作为研究对象,按入院顺序随机分为2组,对照组31例行常规治疗,观察组36例配合下气活血通腑汤治疗;比较2组患者治疗效果、炎症反应、胃肠功能及各项临床症状缓解时间。结果:治疗后,观察组总有效率为100%,对照组总有效率为87.10%,2组总有效率比较,差异有统计学意义(χ^2=4.940,P <0.05)。2组治疗后白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均下降(P <0.05),胃动素(MLT)水平均升高(P <0.05)。治疗后组间比较,观察组IL-6、TNF-α水平显著低于对照组(P <0.05),而MLT水平均高于对照组(P <0.05)。观察组腹痛缓解时间、排气时间、腹胀缓解时间、排便时间及胃管停留时间短于对照组,2组比较,差异有统计学意义(P <0.05)。结论:对结肠癌术后急性炎症性肠梗阻患者配合下气活血通腑汤治疗,显著提高临床疗效、减少炎症因子水平、提高胃肠功能,并缩短各症状缓解时间。

Objective:To explore the effect of Xiaqi Huoxue Tongfu tang for acute inflammatory intestinal obstruction after surgery for colon cancer and its effect on inflammatory factors and gastrointestinal function. Methods:A total of 67 cases of patients with acute inflammatory intestinal obstruction after surgery for colon cancer were divided into the control group and the observation group according to the order of admission,31 and 36 cases in each group respectively. The control group was given routine treatment, and the observation group was additionally treated with Xiaqi Huoxue Tongfu tang. The curative effect, inflammatory responses, gastrointestinal function and remission time of each clinical symptom in the two groups were compared. Results: After treatment, the total effective rate was 100% in the observation group and 87.10% in the control group,the difference being significant(χ^2= 4.940,P < 0.05). After treatment,the levels of interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) in the two groups were decreased(P < 0.05),and the levels of motilin(MTL) were increased(P < 0.05). After treatment,the levels of IL-6 and TNF-αin the observation group were significantly lower than those in the control group(P < 0.05),and the level of MLT was higher than that in the control group(P < 0.05). In the observation group,the remission time of abdominal pain as well as abdominal distension,the anal exhaust time,the defecation time and the residence time of gastric tube were all shorter than those in the control group, the difference being significant(P < 0.05).Conclusion: The additional therapy of Xiaqi Huoxue Tongfu tang for patients with acute inflammatory intestinal obstruction after surgery for colon cancer can significantly improve clinical effect,reduce inflammatory factors,improve gastrointestinal function and shorten the remission time of each symptom.